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Effect of selenium supplementation on changes in glycated haemoglobin (HbA1c ): Results from a multiple-dose, randomized controlled trial

Stranges, Saverio, Rayman, Margaret, Winther, Kristian Hillert, Guallar, Eliseo, Cold, Søren and Pastor-Barriuso, Roberto (2018) Effect of selenium supplementation on changes in glycated haemoglobin (HbA1c ): Results from a multiple-dose, randomized controlled trial Diabetes, Obesity and Metabolism, 21. pp. 541-549.

HbA1cFull Manuscript - DK PRECISE Trial-24September2018.pdf - Accepted version Manuscript

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Long-term selenium supplementation may have adverse effects on glucose metabolism and risk of type-2 diabetes in selenium-replete populations, such as the US. There is limited trial evidence on the effect of selenium supplementation on glucose metabolism in European populations whose selenium status is much lower than that of the US. We investigated the effect of selenium supplementation at different dose levels on changes in HbA1c after 6 months and 2 years in a population of relatively low selenium status.

Materials and methods:

The Denmark PRECISE study was a single-centre, randomized, double-blinded, placebo-controlled, multi-arm, parallel clinical trial with four groups. In total, 491 volunteers aged 60-74 years were randomly assigned to treatment with 100, 200, or 300 µg selenium/d as selenium-enriched-yeast or placebo-yeast. HbA1c measurements were available for 489 participants at baseline, 435 at 6 months, and 369 after 2 years of selenium supplementation. Analyses were performed by intention to treat.


The mean (SD) age, plasma-selenium concentration, and blood HbA1c at baseline were 66.1 (4.1) years, 86.5 (16.3) ng/g, and 36.6 (7.0) mmol/mol, respectively. During the initial 6- month intervention period, mean HbA1c (95% CIs) decreased by 1.5 (-2.8 to -0.2) mmol/mol for 100 µg/d of selenium supplementation and by 0.7 (-2.0 to 0.6) mmol/mol for the 200 and 300 µg/d groups compared with placebo (P = 0.16 for homogeneity of changes across the four groups). After 2 years of selenium supplementation, HbA1c had decreased significantly in all treatment groups, with no difference between active treatment and placebo.


Selenium supplementation in an elderly European population of relatively low selenium status did not significantly affect HbA1c levels after 2 years. Our findings corroborate a possible U-shaped response of selenium supplementation on glucose metabolism.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Stranges, Saverio
Winther, Kristian Hillert
Guallar, Eliseo
Cold, Søren
Pastor-Barriuso, Roberto
Date : 2 October 2018
DOI : 10.1111/dom.13549
Copyright Disclaimer : © 2018 John Wiley & Sons Ltd. This is the peer reviewed version of an article which has been published in Diabetes, Obesity and Metabolism, and it will appear in final form at: This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords : Selenium; Selenium dose; Selenium toxicity; Diabetes; Glycated haemoglobin (HbA1c); Randomized controlled trial
Depositing User : Melanie Hughes
Date Deposited : 03 Oct 2018 14:20
Last Modified : 03 Oct 2019 02:08

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