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Lesion detectability in 2D-mammography and digital breast tomosynthesis using different targets and observers

Elangovan, Premkumar, Mackenzie, Alistair, Dance, David R, Young, Kenneth C and Wells, Kevin (2018) Lesion detectability in 2D-mammography and digital breast tomosynthesis using different targets and observers Physics in Medicine & Biology, 63 (9), 095014. pp. 1-10.

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Abstract

This work investigates the detection performance of specialist and non-specialist observers for different targets in 2D-mammography and digital breast tomosynthesis (DBT) using the OPTIMAM virtual clinical trials (VCT) Toolbox and a 4-alternative forced choice (4AFC) assessment paradigm.

Using 2D-mammography and DBT images of virtual breast phantoms, we compare the detection limits of simple uniform spherical targets and irregular solid masses. Target diameters of 4 mm and 6 mm have been chosen to represent target sizes close to the minimum detectable size found in breast screening, across a range of controlled contrast levels. The images were viewed by a set of specialist observers (five medical physicists and six experienced clinical readers) and five non-specialists.

Combined results from both observer groups indicate that DBT has a significantly lower detectable threshold contrast than 2D-mammography for small masses (4 mm: 2.1% [DBT] versus 6.9% [2D]; 6 mm: 0.7% [DBT] versus 3.9% [2D]) and spheres (4 mm: 2.9% [DBT] versus 5.3% [2D]; 6 mm: 0.3% [DBT] versus 2.2% [2D]) (p  ˂  0.0001). Both observer groups found spheres significantly easier to detect than irregular solid masses for both sizes and modalities (p  ˂  0.0001) (except 4 mm DBT). The detection performances of specialist and non-specialist observers were generally found to be comparable, where each group marginally outperformed the other in particular detection tasks. Within the specialist group, the clinical readers performed better than the medical physicists with irregular masses (p  ˂  0.0001).

The results indicate that using spherical targets in such studies may produce over-optimistic detection thresholds compared to more complex masses, and that the superiority of DBT for detecting masses over 2D-mammography has been quantified. The results also suggest specialist observers may be supplemented by non-specialist observers (with training) in some types of 4AFC studies.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
NameEmailORCID
Elangovan, PremkumarP.Elangovan@surrey.ac.uk
Mackenzie, Alistair
Dance, David R
Young, Kenneth C
Wells, KevinK.Wells@surrey.ac.uk
Date : 4 May 2018
DOI : 10.1088/1361-6560/aabd53
Copyright Disclaimer : © 2018 Institute of Physics and Engineering in Medicine
Uncontrolled Keywords : Virtual clinical trials; Image simulation; 2D-mammography; Digital breast tomosynthesis; 4AFC study; Physicists; Radiologists
Depositing User : Clive Harris
Date Deposited : 17 Sep 2018 14:56
Last Modified : 05 May 2019 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/849305

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