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Walking Speed, Cognitive Function, and Dementia Risk in the English Longitudinal Study of Ageing

Hackett, Ruth A, Davies-Kershaw, Hilary, Cadar, Dorina, Orrell, Martin and Steptoe, Andrew (2018) Walking Speed, Cognitive Function, and Dementia Risk in the English Longitudinal Study of Ageing Journal of the American Geriatrics Society.

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Abstract

OBJECTIVES:

To determine the relationships between walking speed, cognitive function, and the interaction between changes in these measures and dementia risk.

DESIGN:

Longitudinal observational study.

SETTING:

English Longitudinal Study of Ageing.

PARTICIPANTS:

Individuals aged 60 and older (N 5 3,932).

MEASUREMENTS:

Walking speed and cognition were assessed at Waves 1 (2002–03) and 2 (2004–05) of the English Longitudinal Study of Ageing. New dementia cases were assessed from Wave 3 (2006–07) to Wave 7 (2014–15). The associations were modelled using Cox proportional hazards regression.

RESULTS:

Participants with faster baseline walking speeds were at lower risk of developing dementia (hazard ratio (HR) 5 0.36, 95% confidence interval (CI) 5 0.22–0.60). Those with a greater decline in walking speed from Wave 1 to 2 were at greater risk of developing dementia (HR 5 1.23, 95% CI 5 1.03–1.47). Participants with better baseline cognition (HR 5 0.42, 95% CI 5 0.34–0.54) were at lower risk of developing dementia. Those with a greater decline in cognition from Wave 1 to 2 were at greater risk of developing dementia (HR 5 1.78, 95% CI 5 1.53–2.06). Change in walking speed and change in cognition did not have an interactive effect on dementia risk (HR 5 1.01, 95% CI 5 0.88–1.17).

CONCLUSION:

In this community-dwelling sample of English adults, those with slower walking speeds and a greater decline in speed over time were at greater risk of developing dementia independent of changes in cognition. Further research is required to understand the mechanisms that may drive these associations.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Health Sciences
Authors :
NameEmailORCID
Hackett, Ruth A
Davies-Kershaw, Hilaryhilary.davies@surrey.ac.uk
Cadar, Dorina
Orrell, Martin
Steptoe, Andrew
Date : 6 March 2018
Funders : ESRC
DOI : 10.1111/jgs.15312
Copyright Disclaimer : Copyright 2018 The Authors. The Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : gait speed; cognition; dementia
Depositing User : Melanie Hughes
Date Deposited : 29 Aug 2018 11:30
Last Modified : 29 Aug 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/849150

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