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Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity

Aton, Sara J., Seibt, Julie, Dumoulin, Michelle, Jha, Sushil K., Steinmetz, Nicholas, Coleman, Tammi, Naidoo, Nirinjini and Frank, Marcos G. (2009) Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity Neuron, 61 (3). pp. 454-466.

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Abstract

Sleep is thought to consolidate changes in synaptic strength, but the underlying mechanisms are unknown. We investigated the cellular events involved in this process during ocular dominance plasticity (ODP)—a canonical form of in vivo cortical plasticity triggered by monocular deprivation (MD) and consolidated by sleep via undetermined, activity-dependent mechanisms. We find that sleep consolidates ODP primarily by strengthening cortical responses to nondeprived eye stimulation. Consolidation is inhibited by reversible, intracortical antagonism of NMDA receptors (NMDARs) or cAMP-dependent protein kinase (PKA) during post-MD sleep. Consolidation is also associated with sleep-dependent increases in the activity of remodeling neurons and in the phosphorylation of proteins required for potentiation of glutamatergic synapses. These findings demonstrate that synaptic strengthening via NMDAR and PKA activity is a key step in sleep-dependent consolidation of ODP.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Aton, Sara J.
Seibt, Juliej.seibt@surrey.ac.uk
Dumoulin, Michelle
Jha, Sushil K.
Steinmetz, Nicholas
Coleman, Tammi
Naidoo, Nirinjini
Frank, Marcos G.
Date : 11 February 2009
DOI : 10.1016/j.neuron.2009.01.007
Uncontrolled Keywords : SYSNEURO; MOLNEURO; SIGNALING
Depositing User : Melanie Hughes
Date Deposited : 28 Aug 2018 14:41
Last Modified : 28 Aug 2018 14:41
URI: http://epubs.surrey.ac.uk/id/eprint/849134

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