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Visual experience and subsequent sleep induce sequential plastic changes in putative inhibitory and excitatory cortical neurons

Aton, Sara J, Broussard, Christopher, Dumoulin, Michelle, Seibt, Julie, Watson, Adam, Coleman, Tammi and Frank, Marcos G (2013) Visual experience and subsequent sleep induce sequential plastic changes in putative inhibitory and excitatory cortical neurons PNAS, 110 (8). pp. 3101-3106.

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Abstract

Ocular dominance plasticity in the developing primary visual cortex is initiated by monocular deprivation (MD) and consolidated during subsequent sleep. To clarify how visual experience and sleep affect neuronal activity and plasticity, we continuously recorded extragranular visual cortex fast-spiking (FS) interneurons and putative principal (i.e., excitatory) neurons in freely behaving cats across periods of waking MD and post-MD sleep. Consistent with previous reports in mice, MD induces two related changes in FS interneurons: a response shift in favor of the closed eye and depression of firing. Spike-timing–dependent depression of open-eye–biased principal neuron inputs to FS interneurons may mediate these effects. During post-MD nonrapid eye movement sleep, principal neuron firing increases and becomes more phase-locked to slow wave and spindle oscillations. Ocular dominance (OD) shifts in favor of open-eye stimulation—evident only after post-MD sleep—are proportional to MD-induced changes in FS interneuron activity and to subsequent sleep-associated changes in principal neuron activity. OD shifts are greatest in principal neurons that fire 40–300 ms after neighboring FS interneurons during post-MD slow waves. Based on these data, we propose that MD-induced changes in FS interneurons play an instructive role in ocular dominance plasticity, causing disinhibition among open-eye–biased principal neurons, which drive plasticity throughout the visual cortex during subsequent sleep.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Aton, Sara J
Broussard, Christopher
Dumoulin, Michelle
Seibt, Juliej.seibt@surrey.ac.uk
Watson, Adam
Coleman, Tammi
Frank, Marcos G
Date : 19 February 2013
DOI : 10.1073/pnas.1208093110
Uncontrolled Keywords : GABA striate cortex non-REM sleep REM sleep critical period
Depositing User : Melanie Hughes
Date Deposited : 28 Aug 2018 13:55
Last Modified : 28 Aug 2018 13:55
URI: http://epubs.surrey.ac.uk/id/eprint/849131

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