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Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways

Schuurmans, Carol, Armant, Olivier, Nieto, Marta, Stenman, Jan M, Britz, Olivier, Klenin, Natalia, Brown, Craig, Langevin, Lisa-Marie, Seibt, Julie, Tang, Hua , Cunningham, James M, Dyck, Richard, Walsh, Christopher, Campbell, Kenny, Polleux, Franck and Guillemot, Francois (2004) Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways The EMBO Journal, 23 (14). pp. 2892-2902.

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Neocortical projection neurons, which segregate into six cortical layers according to their birthdate, have diverse morphologies, axonal projections and molecular profiles, yet they share a common cortical regional identity and glutamatergic neurotransmission phenotype. Here we demonstrate that distinct genetic programs operate at different stages of corticogenesis to specify the properties shared by all neocortical neurons. Ngn1 and Ngn2 are required to specify the cortical (regional), glutamatergic (neurotransmitter) and laminar (temporal) characters of early-born (lower-layer) neurons, while simultaneously repressing an alternative subcortical, GABAergic neuronal phenotype. Subsequently, later-born (upper-layer) cortical neurons are specified in an Ngn-independent manner, requiring instead the synergistic activities of Pax6 and Tlx, which also control a binary choice between cortical/glutamatergic and subcortical/GABAergic fates. Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Schuurmans, Carol
Armant, Olivier
Nieto, Marta
Stenman, Jan M
Britz, Olivier
Klenin, Natalia
Brown, Craig
Langevin, Lisa-Marie
Tang, Hua
Cunningham, James M
Dyck, Richard
Walsh, Christopher
Campbell, Kenny
Polleux, Franck
Guillemot, Francois
Date : 1 July 2004
DOI : 10.1038/sj.emboj.7600278
Copyright Disclaimer : Copyright 2004 European Molecular Biology Organization. All Rights Reserved
Uncontrolled Keywords : laminar specification, neocortex, Neurogenins, neurotransmitter phenotype
Depositing User : Melanie Hughes
Date Deposited : 28 Aug 2018 13:35
Last Modified : 28 Aug 2018 13:35

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