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Neurogenin2 Specifies the Connectivity of Thalamic Neurons by Controlling Axon Responsiveness to Intermediate Target Cues

Seibt, Julie, Schuurmans, Carol, Gradwhol, Gerard, Dehay, Colette, Vanderhaeghen, Pierre, Guillemot, Francois and Polleux, Frank (2003) Neurogenin2 Specifies the Connectivity of Thalamic Neurons by Controlling Axon Responsiveness to Intermediate Target Cues Neuron, 39 (3). pp. 439-452.

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Abstract

Many lines of evidence indicate that important traits of neuronal phenotype, such as cell body position and neurotransmitter expression, are specified through complex interactions between extrinsic and intrinsic genetic determinants. However, the molecular mechanisms specifying neuronal connectivity are less well understood at the transcriptional level. Here we demonstrate that the bHLH transcription factor Neurogenin2 cell autonomously specifies the projection of thalamic neurons to frontal cortical areas. Unexpectedly, Ngn2 determines the projection of thalamic neurons to specific cortical domains by specifying the responsiveness of their axons to cues encountered in an intermediate target, the ventral telencephalon. Our results thus demonstrate that in parallel to their well-documented proneural function, bHLH transcription factors also contribute to the specification of neuronal connectivity in the mammalian brain

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Seibt, Juliej.seibt@surrey.ac.uk
Schuurmans, Carol
Gradwhol, Gerard
Dehay, Colette
Vanderhaeghen, Pierre
Guillemot, Francois
Polleux, Frank
Date : July 2003
DOI : 10.1016/S0896-6273(03)00435-5
Copyright Disclaimer : Copyright © 2003 Cell Press. All rights reserved.
Depositing User : Melanie Hughes
Date Deposited : 28 Aug 2018 11:55
Last Modified : 28 Aug 2018 11:55
URI: http://epubs.surrey.ac.uk/id/eprint/849121

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