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Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: Randomized-controlled, double-masked intervention trial

Rodriguez-Mateos, Ana, Weber, Timon, Skene, Simon, Ottaviani, Javier I, Crozier, Alan, Kelm, Malte, Schroeter, Hagan and Heiss, Christian (2018) Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: Randomized-controlled, double-masked intervention trial The American Journal of Clinical Nutrition, 108 (6), nqy229. pp. 1229-1237.

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Abstract

Background:

Flavanols are an important class of food bioactives that can improve vascular function even in healthy subjects. Cocoa flavanols (CFs) are comprised principally of the monomer, (−)-epicatechin (~20%) with a degree of polymerisation of 1 (DP1), and oligomeric procyanidins (~80%, DP2-10).

Objective:

To investigate the relative contribution of procyanidins and (−)-epicatechin to CF intake-related improvements in vascular function in healthy volunteers.

Design:

In a randomized, controlled, double-masked, parallel-group dietary intervention trial, 45 healthy men, (18-35 years), consumed once daily for 1 month (a) a DP1-10 cocoa extract containing 130 mg of (−)-epicatechin and 560 mg of procyanidins (b) a DP2-10 cocoa extract containing 20 mg (−)-epicatechin and 540 mg procyanidins or (c) a Control that was flavanol-free with identical micro- and macronutrient composition. (ClinicalTrials.gov NCT02728466)

Results:

Consumption of DP1-10, but neither DP2-10 nor the Control, significantly increased flow-mediated vasodilation (primary endpoint), and the level of structurally-related (−)-epicatechin metabolites (SREMs) in the circulatory system, while decreasing pulse wave velocity and blood pressure. Total cholesterol significantly decreased after daily intake of both DP1-10 and DP2-10 as compared to the Control.

Conclusions:

CF-related improvements in vascular function predominantly relate to intake of flavanol monomers and circulating SREMs in healthy humans, but not to the more abundant procyanidins and gut microbiome-derived CF-catabolites. Reduction in total cholesterol was linked to consumption of procyanidins but not necessarily that of (-)-epicatechin.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Rodriguez-Mateos, Anaa.rodriguez-mateos@surrey.ac.uk
Weber, Timon
Skene, Simons.skene@surrey.ac.uk
Ottaviani, Javier I
Crozier, Alan
Kelm, Malte
Schroeter, Hagan
Heiss, Christianc.heiss@surrey.ac.uk
Date : December 2018
DOI : 10.1093/ajcn/nqy229
Copyright Disclaimer : © 2018 American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : cocoa; epicatechin: procyanidins; hydroxy-phenylvalerolactones; structurally-related (-)-epicatechin metabolites; endothelial function; blood pressure
Depositing User : Melanie Hughes
Date Deposited : 21 Aug 2018 14:22
Last Modified : 18 Jun 2019 10:41
URI: http://epubs.surrey.ac.uk/id/eprint/849058

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