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Improved endothelial function and decreased levels of endothelium-derived microparticles after transcatheter aortic valve implantation

Horn, Patrick, Stern, Daniel, Veulemans, Verena, Heiss, Christian, Zeus, Tobias, Merx, Marc W., Kelm, Malte and Westenfeld, Ralf (2015) Improved endothelial function and decreased levels of endothelium-derived microparticles after transcatheter aortic valve implantation EuroIntervention, 10 (12). pp. 1456-1463.

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Abstract

AIMS:

Degenerative aortic valve stenosis (AVS) is independently associated with endothelial dysfunction and increased levels of circulating endothelium-derived microparticles (EMPs) as a marker of compromised endothelial integrity. The aim of this study was to investigate whether therapy for severe AVS by transcatheter aortic valve implantation (TAVI) improves endothelial function and decreases EMPs.

METHODS AND RESULTS:

Fifty-six patients with indication for TAVI due to symptomatic severe AVS were prospectively enrolled. Brachial wall shear stress (WSS), endothelial function and circulating microparticles (MPs) were measured before and three months following TAVI. Endothelial function was assessed as flow-mediated dilation (FMD) using ultrasound. MP subpopulations were discriminated by flow cytometry according to the expression of established surface antigens: CD31+/CD41-, CD144+ and CD62E+ as EMPs and CD41+ as platelet-derived MPs (PMPs). In patients with severe AVS, decreased brachial WSS was an independent predictor of low FMD. At three-month follow-up after TAVI, WSS and FMD increased along with decreased levels of EMPs as compared to pre TAVI. Decrease of CD31+/CD41-, CD144+ and CD62E+ EMP levels correlated with the increase of FMD.

CONCLUSIONS:

Therapy for AVS by TAVI was associated with improved endothelial function and integrity indicating beneficial effects of TAVI on systemic arterial function.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Horn, Patrick
Stern, Daniel
Veulemans, Verena
Heiss, Christianc.heiss@surrey.ac.uk
Zeus, Tobias
Merx, Marc W.
Kelm, Malte
Westenfeld, Ralf
Date : 1 April 2015
DOI : 10.4244/EIJY14M10_02
Copyright Disclaimer : © 2005-2015 Europa Group - All rights reserved
Uncontrolled Keywords : Aortic valve stenosis; Transcatheter aortic valve implantation; Endothelial function; Endothelial integrity; Microparticles
Depositing User : Diane Maxfield
Date Deposited : 20 Aug 2018 09:53
Last Modified : 20 Aug 2018 09:53
URI: http://epubs.surrey.ac.uk/id/eprint/849043

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