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Early and late response-to-injury in patients undergoing transradial coronary angiography: arterial remodeling in smokers

Sansone, Roberto, Stegemann, Emilia, Özaslan, Göksen, Schuler, Dominik, Lukosz, Margarete, Rodriguez-Mateos, Ana, Lauer, Thomas, Westenfeld, Ralf, Kelm, Malte and Heiss, Christian (2014) Early and late response-to-injury in patients undergoing transradial coronary angiography: arterial remodeling in smokers American Journal of Cardiovascular Disease, 4 (2). pp47-57.

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Objectives: To investigate the effect of smoking on vascular response to transradial coronary angiography (TCA). Background: Cigarette smoking is the most important modifiable cardiovascular risk factor associated with endothelial dysfunction. Methods: Radial artery flow-mediated vasodilation (RA-FMD), local stiffness (fractional diameter change), intima-media thickness (IMT), luminal and external arterial diameter were measured in 40 current smokers (CS) and former smokers (FS) at 6-14 months at the site of previous TCA and contralateral control artery. Vascular regenerative capacity was studied as chemotactic cell migration in vitro and ex vivo (n=10) and the time course of endothelial functional recovery following RA-FMD up to 72 h after TCA (n=10). Results: At 10 ± 3 months after TCA, subjects exhibited significant local stiffening and increased IMT as compared to the control arm. These late structural changes were significantly more pronounced in CS as compared to FS. IMT thickening correlated with packyears, number of daily cigarettes, and inversely with RA-FMD. Nitric oxide synthase (NOS)-dependent chemotaxis of CS’ circulating angiogenic cells was impaired. Ex vivo incubation of endothelial cells with CS’ plasma inhibited NOS-dependent endothelial wound closure and chemotaxis. In vivo, TCA acutely decreased RA-FMD. At 24 h, RA-FMD had recovered in FS but remained impaired at 24 h and only recovered at 48 h in CS. Conclusion: In active smokers, transradial coronary angiography is associated with delayed early recovery from transient endothelial dysfunction, decreased NOS-dependent vascular regeneration, and late arterial remodeling pointing towards potential harmful effects of transradial coronary angiography on vascular function in distinct subsets of patients.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Faculty of Health and Medical Sciences > School of Health Sciences
Faculty of Health and Medical Sciences
Authors :
Sansone, Roberto
Stegemann, Emilia
Özaslan, Göksen
Schuler, Dominik
Lukosz, Margarete
Rodriguez-Mateos, Ana
Lauer, Thomas
Westenfeld, Ralf
Kelm, Malte
Date : 28 June 2014
Copyright Disclaimer : AJCD Copyright © 2014
Uncontrolled Keywords : Smoking; Intima media thickness; Transradial coronary angiography; Endothelial function; Prevention
Depositing User : Diane Maxfield
Date Deposited : 17 Aug 2018 15:50
Last Modified : 17 Aug 2018 15:50

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