University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Brief Exposure to Secondhand Smoke Reversibly Impairs Endothelial Vasodilatory Function

Pinnamaneni, Kranthi, Sievers, Richard E., Sharma, Rikki, Selchau, Amanda M., Gutierrez, Gustavo, Nordsieck, Eric J., Su, Robert, An, Songtao, Chen, Qiumei, Wang, Xiaoyin , Derakhshandeh, Ronak, Aschbacher, Kirstin, Heiss, Christian, Glantz, Stanton A., Schick, Suzaynn F. and Springer, Matthew L. (2013) Brief Exposure to Secondhand Smoke Reversibly Impairs Endothelial Vasodilatory Function Nicotine & Tobacco Research, 16 (5). pp. 584-590.

Full text not available from this repository.

Abstract

Introduction:

We sought to determine the effects of brief exposures to low concentrations of tobacco secondhand smoke (SHS) on arterial flow-mediated dilation (FMD, a nitric oxide-dependent measure of vascular endothelial function), in a controlled animal model never before exposed to smoke. In humans, SHS exposure for 30min impairs FMD. It is important to gain a better understanding of the acute effects of exposure to SHS at low concentrations and for brief periods of time.

Methods:

We measured changes in FMD in rats exposed to a range of real-world levels of SHS for durations of 30min, 10min, 1min, and 4 breaths (roughly 15 s).

Results:

We observed a dose-response relationship between SHS particle concentration over 30min and post-exposure impairment of FMD, which was linear through the range typically encountered in smoky restaurants and then saturated at higher concentrations. One min of exposure to SHS at moderate concentrations was sufficient to impair FMD.

Conclusions:

Brief SHS exposure at real-world levels reversibly impairs FMD. Even 1min of SHS exposure can cause reduction of endothelial function.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Pinnamaneni, Kranthi
Sievers, Richard E.
Sharma, Rikki
Selchau, Amanda M.
Gutierrez, Gustavo
Nordsieck, Eric J.
Su, Robert
An, Songtao
Chen, Qiumei
Wang, Xiaoyin
Derakhshandeh, Ronak
Aschbacher, Kirstin
Heiss, Christianc.heiss@surrey.ac.uk
Glantz, Stanton A.
Schick, Suzaynn F.
Springer, Matthew L.
Date : 3 December 2013
DOI : 10.1093/ntr/ntt189
Copyright Disclaimer : © The Author 2013. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved.
Uncontrolled Keywords : Passive smoking; Exposure; Dilatation; Pathologic; Dose-response relationship; Drug; Endothelium; Animal model; Oxides; Restaurants; Smoke; Tobacco; Rats; Fluid flow
Depositing User : Diane Maxfield
Date Deposited : 17 Aug 2018 13:37
Last Modified : 17 Aug 2018 13:37
URI: http://epubs.surrey.ac.uk/id/eprint/849026

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800