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Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients

Horn, Patrick, Amabile, Nicolas, Angeli, Franca S., Sansone, Roberto, Stegemann, Berthold, Kelm, Malte, Springer, Matthew L., Yeghiazarians, Yerem, Schroeter, Hagen and Heiss, Christian (2014) Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients BRITISH JOURNAL OF NUTRITION, 111 (07). pp. 1245-1252.

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Abstract

Current evidence suggests that regenerative v. degenerative endothelial responses can be integrated in a clinical endothelial phenotype, reflecting the net result between damage from risk factors and endogenous repair capacity. We have previously shown that a cocoa flavanol (CF) intervention can improve endothelial function and increase the regenerative capacity of the endothelium by mobilising circulating angiogenic cells in patients with coronary artery disease (CAD). The aim of the present study was to investigate whether CF can lower the levels of circulating endothelial microparticles (EMP), markers of endothelial integrity, along with improvements in endothelial function. The levels of EMP in the frozen plasma samples of CAD patients were measured along with endothelial function (flow-mediated vasodilation, FMD); n 16, FMD data published previously), and these data were compared with those of young (n 12) and age-matched (n 12) healthy control subjects. The CAD patients exhibited significantly increased levels of EMP along with impaired FMD when compared with the healthy control subjects. The levels of CD144+ and CD31+/41− EMP were inversely correlated with FMD (r − 0·67, P= 0·01 and r − 0·59, P= 0·01, respectively). In these CAD patients, the levels of EMP were measured after they had consumed a drink containing 375 mg of CF (high-CF intervention, HiFI) or 9 mg of CF (macro- and micronutrient-matched low-CF control, LoFl) twice daily over a 30-d period in a randomised, double-blind, cross-over study. After 1 month of HiFI, the levels of CD31+/41− and CD144+ EMP decreased ( − 25 and − 23 %, respectively), but not after LoFl. Our data show that flavanols lower the levels of EMP along with higher endothelial function, lending evidence to the novel concept that flavanols may improve endothelial integrity.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Faculty of Health and Medical Sciences > School of Health Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Horn, Patrick
Amabile, Nicolas
Angeli, Franca S.
Sansone, Roberto
Stegemann, Berthold
Kelm, Malte
Springer, Matthew L.
Yeghiazarians, Yerem
Schroeter, Hagen
Heiss, Christianc.heiss@surrey.ac.uk
Date : 14 April 2014
Identification Number : 10.1017/S0007114513003693
Copyright Disclaimer : Copyright The Authors 2013
Uncontrolled Keywords : Cocoa flavanols; Endothelial integrity; Endothelial function; Endothelial microparticles
Depositing User : Diane Maxfield
Date Deposited : 17 Aug 2018 12:09
Last Modified : 17 Aug 2018 12:09
URI: http://epubs.surrey.ac.uk/id/eprint/849017

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