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Oxygen dependence of endothelium-dependent vasodilation: importance in chronic obstructive pulmonary disease

Keymel, Stefanie, Schueller, Benedikt, Sansone, Roberto, Wagstaff, Rabea, Steiner, Stephan, Kelm, Malte and Heiss, Christian (2016) Oxygen dependence of endothelium-dependent vasodilation: importance in chronic obstructive pulmonary disease Archives of Medical Science, 14 (2). pp. 297-306.

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Introduction: Epidemiological studies have shown increased morbidity and mortality in patients with coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). We aimed to characterize the oxygen dependence of endothelial function in patients with CAD and coexisting COPD. Go to: Material and methods: In CAD patients with and without COPD (n = 33), we non-invasively measured flow-mediated dilation (FMD) and intima-media thickness (IMT) of the brachial artery (BA), forearm blood flow (FBF), and perfusion of the cutaneous microcirculation with laser Doppler perfusion imaging (LDPI). In an experimental setup, vascular function was assessed in healthy volunteers (n = 5) breathing 12% oxygen or 100% oxygen in comparison to room air. Go to: Results: COPD was associated with impaired FMD (3.4 ±0.5 vs. 4.2 ±0.6%; p < 0.001) and increased IMT (0.49 ±0.04 vs. 0.44 ±0.04 mm; p <0.01), indicating functional and structural alterations of the BA in COPD. Forearm blood flow and LDPI were comparable between the groups. Flow-mediated dilation correlated with capillary oxygen pressure (pO2, r = 0.608). Subgroup analysis in COPD patients with pO2 > 65 mm Hg and pO2 ≤ 65 mm Hg revealed even lower FMD in patients with lower pO2 (3.0 ±0.5 vs. 3.7 ±0.4%; p < 0.01). Multivariate analysis showed that pO2 was a predictor of FMD independent of the forced expiratory volume and pack years. Exposure to hypoxic air led to an acute decrease in FMD, whereby exposure to 100% oxygen did not change vascular function. Conclusions: Our data suggest that in CAD patients with COPD, decreased systemic oxygen levels lead to endothelial dysfunction, underlining the relevance of cardiopulmonary interaction and the potential importance of pulmonary treatment in secondary prevention of vascular disease.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Keymel, Stefanie
Schueller, Benedikt
Sansone, Roberto
Wagstaff, Rabea
Steiner, Stephan
Kelm, Malte
Date : 24 March 2016
DOI : 10.5114/aoms.2016.58854
Uncontrolled Keywords : chronic obstructive pulmonary disease, coronary artery disease, endothelial function, flow-mediated dilation, intima media thickness, oxygen
Depositing User : Melanie Hughes
Date Deposited : 16 Aug 2018 14:33
Last Modified : 16 Aug 2018 14:33

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