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Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry

Feliciano, Rodrigo, Istas, Geoffrey, Heiss, Christian and Rodriguez-Mateos, Ana (2016) Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry Molecules, 21 (9), 1120.

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Abstract

Recent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variability in plasma and urinary polyphenol levels was also investigated. Blood samples were collected at baseline and 2 h post-consumption on day 1 and day 30. Twenty-four-hour urine was also collected on both days. A total of 61 phenolic metabolites were quantified in plasma at baseline, of which 43 increased after acute or chronic consumption of blueberries over one month. Benzoic and catechol derivatives represented more than 80% of the changes in phenolic profile after 2 h consumption on day 1, whereas hippuric and benzoic derivatives were the major compounds that increased at 0 and 2 h on day 30, respectively. The total (poly)phenol urinary excretion remained unchanged after 30 days of wild blueberry intake. The inter-individual variability ranged between 40%–48% in plasma and 47%–54% in urine. Taken together, our results illustrate that blueberry (poly)phenols are absorbed and extensively metabolized by phase II enzymes and by the gut microbiota, leading to a whole array of metabolites that may be responsible for the beneficial effects observed after blueberry consumption.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Feliciano, Rodrigo
Istas, Geoffrey
Heiss, Christianc.heiss@surrey.ac.uk
Rodriguez-Mateos, Ana
Date : 25 August 2016
DOI : 10.3390/molecules21091120
Uncontrolled Keywords : (poly)phenols; blueberry; acute; chronic; plasma; urine; inter-individual variability
Depositing User : Melanie Hughes
Date Deposited : 16 Aug 2018 13:27
Last Modified : 16 Aug 2018 13:27
URI: http://epubs.surrey.ac.uk/id/eprint/848984

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