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Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis

Merx, Marc W., Horn, Patrick, Erkilet, Gülsüm, Veulemans, Verena, Kröpil, Patric, Schurgers, Leon, Zeus, Tobias, Heiss, Christian, Kelm, Malte and Westenfeld, Ralf (2016) Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis PLOS ONE, 11 (3), e0151499.

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Abstract

Background

Circulating microparticles (MPs) derived from endothelial cells and blood cells bear procoagulant activity and promote thrombin generation. Thrombin exerts proinflammatory effects mediating the progression of atherosclerosis. Aortic valve stenosis may represent an atherosclerosis-like process involving both the aortic valve and the vascular system. The aim of this study was to investigate whether MP-induced thrombin generation is related to coronary atherosclerosis and aortic valve calcification.

Methods

In a cross-sectional study of 55 patients with severe aortic valve stenosis, we assessed the coronary calcification score (CAC) as indicator of total coronary atherosclerosis burden, and aortic valve calcification (AVC) by computed tomography. Thrombin-antithrombin complex (TATc) levels were measured as a marker for thrombin formation. Circulating MPs were characterized by flow cytometry according to the expression of established surface antigens and by measuring MP-induced thrombin generation.

Results

Patients with CAC score below the median were classified as patients with low CAC, patients with CAC Score above the median as high CAC. In patients with high CAC compared to patients with low CAC we detected higher levels of TATc, platelet-derived MPs (PMPs), endothelial-derived MPs (EMPs) and MP-induced thrombin generation. Increased level of PMPs and MP-induced thrombin generation were independent predictors for the severity of CAC. In contrast, AVC Score did not differ between patients with high and low CAC and did neither correlate with MPs levels nor with MP-induced thrombin generation.

Conclusion

In patients with severe aortic valve stenosis MP-induced thrombin generation was independently associated with the severity of CAC but not AVC indicating different pathomechanisms involved in coronary artery and aortic valve calcification.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Merx, Marc W.
Horn, Patrick
Erkilet, Gülsüm
Veulemans, Verena
Kröpil, Patric
Schurgers, Leon
Zeus, Tobias
Heiss, Christianc.heiss@surrey.ac.uk
Kelm, Malte
Westenfeld, Ralf
Date : 24 March 2016
DOI : 10.1371/journal.pone.0151499
Depositing User : Melanie Hughes
Date Deposited : 16 Aug 2018 13:04
Last Modified : 16 Aug 2018 13:04
URI: http://epubs.surrey.ac.uk/id/eprint/848980

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