University of Surrey

Test tubes in the lab Research in the ATI Dance Research

TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention

Kehmeier, Eva S., Lepper, Wolfgang, Kropp, Martina, Heiss, Christian, Hendgen-Cotta, Ulrike, Balzer, Jan, Neizel, Mirja, Meyer, Christian, Merx, Marc W., Verde, P , Ohmann, Christian, Heusch, Gerd, Kelm, Malte and Rassaf, Tienush (2012) TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention Clinical Research in Cardiology, 101 (10). pp. 815-827.

Full text not available from this repository.

Abstract

Aims To characterize the time course of tumor necrosis factor-α (TNF-α) serum levels along with myocardial perfusion and contractile function in patients with ST-segment elevation myocardial infarction (STEMI) and successful primary percutaneous coronary intervention (PCI). Methods Serum levels of TNF-α, interleukin 6 (IL-6), and C-reactive protein (CRP) were measured in 42 patients with STEMI before, one and 6 days after successful PCI. Myocardial perfusion was assessed by contrast-enhanced echocardiography (ceEcho), contractile function by unenhanced two-dimensional (2DE) and real-time three-dimensional echocardiography. In a subset of 18 patients, infarct size was quantified by late gadolinium enhancement cardiovascular magnetic resonance imaging (LGE-CMR) on day six. Results TNF-α serum levels were in the upper normal range within the first 12 h from symptom onset and increased continuously until day six, while IL-6 and CRP increased subsequently with a peak on day one after STEMI. Serum TNF-α on day one after PCI correlated with perfusion defects, wall motion abnormalities, and infarct size (ceEcho: r = 0.52, p = 0.005; 2DE: r = 0.56, p = 0.002; LGE-CMR: r = 0.83–0.86; p < 0.0001). Using multiple regression linear analysis, infarct size on day six was predicted by serum TNF-α 1 day after PCI (p = 0.006, adjusted R 2 0.638). Conclusion Our data reflect the clinical significance of early TNF-α elevation in patients with STEMI and primary PCI (Controlled Clinical Trials number, NCT00529607).

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Kehmeier, Eva S.
Lepper, Wolfgang
Kropp, Martina
Heiss, Christianc.heiss@surrey.ac.uk
Hendgen-Cotta, Ulrike
Balzer, Jan
Neizel, Mirja
Meyer, Christian
Merx, Marc W.
Verde, P
Ohmann, Christian
Heusch, Gerd
Kelm, Malte
Rassaf, Tienush
Date : 6 May 2012
DOI : 10.1007/s00392-012-0465-x
Copyright Disclaimer : Copyright Springer-Verlag 2012
Uncontrolled Keywords : Contractile function; Infarct size; Myocardial perfusion; PCI; STEMI; TNF-α
Depositing User : Diane Maxfield
Date Deposited : 16 Aug 2018 12:30
Last Modified : 16 Aug 2018 12:30
URI: http://epubs.surrey.ac.uk/id/eprint/848979

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800