University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood

Schanz, Andrea, Winn, Virginia D., Fisher, Susan J., Blumenstein, Marion, Heiss, Christian, Hess, Alexandra P., Kruessel, Jan S., Mcmaster, Michael and North, Robyn A. (2011) Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood European Journal of Obstetrics and Gynecology and Reproductive Biology, 157 (1). pp. 32-37.

Full text not available from this repository.

Abstract

Objectives

Placental derived vasculogenic/angiogenic substances in maternal blood are dysregulated in pre-eclampsia. We hypothesized that CXCL12, a chemokine with vasculogenic actions, is amongst such molecules.

Study design

CXCL12, CXCL16, CXCR4, and CXCR6 immunolocalization in placental tissue was analyzed in pre-eclampsia (n = 8) in comparison to controls (n = 8). CXCL12, measured by ELISA in blood, in women diagnosed with pre-eclampsia (n = 14) and prior to the development of pre-eclampsia (at 20 weeks’ gestation, n = 20) was compared with CXCL12 concentrations in gestation-matched, healthy control subjects (n = 34).

Results

In placental tissue, syncytiotrophoblast staining for CXCL12 was increased in pre-eclampsia. Maternal serum CXCL12 was increased in pre-eclampsia [2000 (SD 402) vs 1484 (SD 261) pg/ml, P = 0.01] but not in plasma obtained at 20 weeks of gestation prior to the onset of pre-eclampsia [1183 (SD 336) vs 1036 (SD 144) pg/ml, P = 0.09].

Conclusion

Our data suggest that the syncytiotrophoblast contributes to a pre-eclampsia-associated increase in CXCL12 levels in maternal blood. These findings support the hypothesis that an imbalance of angiogenic factors contributes to the pathogenesis of pre-eclampsia.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Schanz, Andrea
Winn, Virginia D.
Fisher, Susan J.
Blumenstein, Marion
Heiss, Christianc.heiss@surrey.ac.uk
Hess, Alexandra P.
Kruessel, Jan S.
Mcmaster, Michael
North, Robyn A.
Date : 30 March 2011
DOI : 10.1016/j.ejogrb.2011.02.023
Copyright Disclaimer : Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Uncontrolled Keywords : Chemokine; CXCL12; Placenta; Pre-eclampsia; Stromal cell derived-factor-1 alpha
Depositing User : Diane Maxfield
Date Deposited : 16 Aug 2018 09:43
Last Modified : 16 Aug 2018 09:43
URI: http://epubs.surrey.ac.uk/id/eprint/848968

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800