University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial

Heiss, Christian, Sansone, Roberto, Karimi, Hakima, Krabbe, Moritz, Schuler, Dominik, Rodriguez-Mateos, Ana, Kraemer, Thomas, Cortese-Krott, Miriam Margherita, Kuhnle, Gunter G. C., Spencer, Jeremy P. E. , Schroeter, Hagen, Merx, Marc W. and Kelm, Malte (2015) Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial AGE, 37, 56.

Full text not available from this repository.

Abstract

Increased vascular stiffness, endothelial dysfunction, and isolated systolic hypertension are hallmarks of vascular aging. Regular cocoa flavanol (CF) intake can improve vascular function in healthy young and elderly at-risk individuals. However, the mechanisms underlying CF bioactivity remain largely unknown. We investigated the effects of CF intake on cardiovascular function in healthy young and elderly individuals without history, signs, or symptoms of cardiovascular disease by applying particular focus on functional endpoints relevant to cardiovascular aging. In a randomized, controlled, double-masked, parallel-group dietary intervention trial, 22 young (<35 years) and 20 elderly (50–80 year) healthy, male non-smokers consumed either a CF-containing drink (450 mg CF) or nutrient-matched, CF-free control drink bi-daily for 14 days. The primary endpoint was endothelial function as measured by flow-mediated vasodilation (FMD). Secondary endpoints included cardiac output, vascular stiffness, conductance of conduit and resistance arteries, and perfusion in the microcirculation. Following 2 weeks of CF intake, FMD improved in young (6.1 ± 0.7 vs. 7.6 ± 0.7 %, p < 0.001) and elderly (4.9 ± 0.6 vs. 6.3 ± 0.9 %, p < 0.001). Secondary outcomes demonstrated in both groups that CF intake decreased pulse wave velocity and lowered total peripheral resistance, and increased arteriolar and microvascular vasodilator capacity, red cell deformability, and diastolic blood pressure, while cardiac output remained affected. In the elderly, baseline systolic blood pressure was elevated, driven by an arterial-stiffness-related augmentation. CF intake decreased aortic augmentation index (−9 %) and thus systolic blood pressure (−7 mmHg; Clinicaltrials.gov: NCT01639781). CF intake reverses age-related burden of cardiovascular risk in healthy elderly, highlighting the potential of dietary flavanols to maintain cardiovascular health.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Heiss, Christianc.heiss@surrey.ac.uk
Sansone, Roberto
Karimi, Hakima
Krabbe, Moritz
Schuler, Dominik
Rodriguez-Mateos, Ana
Kraemer, Thomas
Cortese-Krott, Miriam Margherita
Kuhnle, Gunter G. C.
Spencer, Jeremy P. E.
Schroeter, Hagen
Merx, Marc W.
Kelm, Malte
Date : 27 May 2015
DOI : 10.1007/s11357-015-9794-9
Uncontrolled Keywords : Age; Blood pressure; Arterial stiffness; Endothelial function; Nutrition
Depositing User : Melanie Hughes
Date Deposited : 16 Aug 2018 09:26
Last Modified : 16 Aug 2018 09:26
URI: http://epubs.surrey.ac.uk/id/eprint/848965

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800