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Cardiovascular remodeling after AVF surgery in rats assessed by a clinical MRI scanner

Langer, Stephan, Paulus, Niklas, Heiss, Christian, Koeppel, Thomas A., Greiner, Andreas, Buhl, Alexandra, Lauer, Thomas, Kokozidou, Maria, Jacobs, Michael J. and Krombach, Gabriele A. (2011) Cardiovascular remodeling after AVF surgery in rats assessed by a clinical MRI scanner MAGNETIC RESONANCE IMAGING, 29 (1). pp. 57-63.

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Abstract

Purpose

To evaluate a cardiovascular magnetic resonance imaging (MRI) technique which allows the longitudinal analysis of cardiovascular remodeling in a rodent femoral arteriovenous fistula (AVF) model by means of a clinical scanner.

Materials and Methods

Eight rats underwent femoral AVF surgery and four rats served as controls. Vascular and cardiac morphology as well as cardiac function was assessed from Week 3 to 12 using contrast-enhanced, time-resolved magnetic resonance angiography (MRA) and cardiac MRI (cine gradient-echo sequence) at 3 T in one imaging session.

Results

Arteriovenous surgery resulted in progressive venous dilation and a subsequent cardiac adaptation. This procedure led to downstream vasodilation of the iliac vein and inferior vena cava of 179% and 188%, respectively (3 weeks). To accommodate the increased returning blood volume, cardiac output (CO) increased significantly (P=.014; 6 weeks). This was caused by increased end-diastolic volume (EDV), stroke volume (SV) and heart rate (HR) consistent with an increased volume load. A continuous increase in heart weight peaked at 12 weeks. This increase combined with a distinct end-diastolic left ventricular dilation implied eccentric hypertrophy.

Conclusion

Small rodent MRI is feasible and clearly depicts fistula maturation and cardiac alterations. This technique proved to be a valuable tool for longitudinal in vivo monitoring in this model, which strongly resembles clinical findings in hemodialysis patients.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Langer, Stephan
Paulus, Niklas
Heiss, Christianc.heiss@surrey.ac.uk
Koeppel, Thomas A.
Greiner, Andreas
Buhl, Alexandra
Lauer, Thomas
Kokozidou, Maria
Jacobs, Michael J.
Krombach, Gabriele A.
Date : January 2011
DOI : 10.1016/j.mri.2010.07.010
Copyright Disclaimer : Copyright © 2011 Elsevier Inc. All rights reserved.
Uncontrolled Keywords : Arteriovenous fistula; Animal model; Cardiovascular MRI
Depositing User : Diane Maxfield
Date Deposited : 15 Aug 2018 15:20
Last Modified : 15 Aug 2018 15:20
URI: http://epubs.surrey.ac.uk/id/eprint/848956

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