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Fabrication and Optimization of Fiber-Based Lithium Sensor: A Step towards Wearable Sensors for Lithium Drug Monitoring in Interstitial Fluid

Sweilam, Mona N., Varcoe, John R. and Crean, Carol (2018) Fabrication and Optimization of Fiber-Based Lithium Sensor: A Step towards Wearable Sensors for Lithium Drug Monitoring in Interstitial Fluid ACS Sensors, 3 (9). pp. 1802-1810.

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Abstract

A miniaturized, flexible fiber-based lithium sensor was fabricated from low-cost cotton using a simple, repeatable dip-coating technique. This lithium sensor is highly suited for ready-to-use wearable applications and can be used directly without the preconditioning steps normally required with traditional ion-selective electrodes. The sensor has a stable, rapid and accurate response over a wide Li+ concentration range that spans over the clinically effective and the toxic concentration limits for lithium in human serum. The sensor is selective to Li+ in human plasma even in the presence of a high concentration of Na+ ions. This novel sensor concept represents a significant advance in wearable sensor technology which will target lithium drug monitoring from under the skin.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Sweilam, Mona N.
Varcoe, John R.J.Varcoe@surrey.ac.uk
Crean, Carolc.crean@surrey.ac.uk
Date : 10 August 2018
Funders : Engineering and Physical Sciences Research Council (EPSRC)
DOI : 10.1021/acssensors.8b00528
Grant Title : High Spec Raman Spectrometer Regional Facility
Copyright Disclaimer : Copyright © 2018 American Chemical Society
Uncontrolled Keywords : Electrochemical analysis; Wearable sensor; Ion-selective electrode; Fiber; Conductive cotton; Lithium sensor; Non-invasive monitoring
Related URLs :
Depositing User : Clive Harris
Date Deposited : 13 Aug 2018 01:08
Last Modified : 11 Aug 2019 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/848900

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