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Absence of morningness alleles in non-European populations

Emmanuel, Paul and von Schantz, Malcolm (2018) Absence of morningness alleles in non-European populations Chronobiology International.

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Absence of morningness alleles in non-European populations.doc - Accepted version Manuscript
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Abstract

In spite of suspected circadian differences between different ancestral groups, most human studies have used individuals of European descent. This also applies to three recent genome-wide association studies (GWAS), which pinpointed a number of chronotype loci. We investigated the distribution of these hits in different 1000 Genomes populations. We found six out of the 41 alleles previously identified by GWAS in European participants (in the genes RGS16, PER2, AK5, and between the genes APH1A and CA14) to be absent from some non-European population groups. This highlights the need for ancestral diversity in circadian research, and may reflect differences affecting the phenotype of individuals of East Asian ancestry.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Emmanuel, Paul
von Schantz, MalcolmM.Von.Schantz@surrey.ac.uk
Date : 7 August 2018
DOI : 10.1080/07420528.2018.1506928
Copyright Disclaimer : This is an Accepted Manuscript of an article published by Taylor & Francis in Chronobiology International on 7 August 2018, available online: http://www.tandfonline.com/10.1080/07420528.2018.1506928
Uncontrolled Keywords : Chronotype; Circadian rhythms; Diurnal preference; Genetics Genome-wide association studies
Depositing User : Clive Harris
Date Deposited : 30 Jul 2018 12:47
Last Modified : 08 Nov 2018 14:36
URI: http://epubs.surrey.ac.uk/id/eprint/848804

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