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Coagulation cascade and complement system in systemic lupus erythematosus

Liang, Yan, Xie, Shang-Bo, Wu, Changhao, Hu, Yuan, Zhang, Qin, Li, Si, Fan, Yin-Guang, Leng, Rui-Xue, Pan, Hai-Feng, Xiong, Hua-Bao and Ye, Dong-Qing (2018) Coagulation cascade and complement system in systemic lupus erythematosus Oncotarget, 9. pp. 14862-14881.

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Abstract

This study was conducted to (1) characterize coagulation cascade and complement system in systemic lupus erythematosus (SLE); (2) evaluate the associations between coagulation cascade, complement system, inflammatory response and SLE disease severity; (3) test the diagnostic value of a combination of D-dimer and C4 for lupus activity. Transcriptomics, proteomics and metabolomics were performed in 24 SLE patients and 24 healthy controls. The levels of ten coagulations, seven complements and three cytokines were measured in 112 SLE patients. Clinical data were collected from 2025 SLE patients. The analysis of multi-omics data revealed the common links for the components of coagulation cascade and complement system. The results of ELISA showed coagulation cascade and complement system had an interaction effect on SLE disease severity, this effect was pronounced among patients with excess inflammation. The analysis of clinical data revealed a combination of D-dimer and C4 provided good diagnostic performance for lupus activity. This study suggested that coagulation cascade and complement system become ‘partners in crime’, contributing to SLE disease severity and identified the diagnostic value of D-dimer combined with C4for lupus activity.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Liang, Yan
Xie, Shang-Bo
Wu, ChanghaoC.Wu@surrey.ac.uk
Hu, Yuan
Zhang, Qin
Li, Si
Fan, Yin-Guang
Leng, Rui-Xue
Pan, Hai-Feng
Xiong, Hua-Bao
Ye, Dong-Qing
Date : 13 March 2018
DOI : 10.18632/oncotarget.23206
Copyright Disclaimer : Copyright 2018 The Author(s). Published under a Creative Commons Attribution License (CC BY) which allows anyone to download, reuse, reprint, modify, distribute, and/or copy articles in Oncotarget, so long as the original authors and source are cited.
Uncontrolled Keywords : Systemic lupus erythematosus; Coagulation cascade; Complement system; Biomarker; Omics
Depositing User : Clive Harris
Date Deposited : 26 Jul 2018 00:04
Last Modified : 26 Jul 2018 00:04
URI: http://epubs.surrey.ac.uk/id/eprint/848788

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