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Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)

Langat, Moses, Helfenstein, A, Horner, C, Tammel, P, Hokkanen, H, Izotov, D and Mulholland, Dulcie (2018) Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae) Chemistry and Biodiversity, 15 (10), e1800056.

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Abstract

Pumilol (1), a strobane diterpenoid, reported herein for the first time was isolated from the bark of Pinus pumila (Pall.) Regel (Siberian Dwarf Pine or Japanese Stone Pine), along with seventeen known compounds including serratane triterpenoids, not previously reported from this species, and four ferulate derivatives. The stereostructure of pumilol was established using HRESIMS, NMR, the DP4+ probabilities and by comparison of the experimental and calculated electronic circular dichroim (ECD) spectra. Labda-8(17),13-dien-15-oic acid (4), bornyl trans-4-hydroxycinnamate (14) and E-bornyl ferulate (15) showed activity against S. aureus and/or E. faecalis with MIC90 values 12.5-50 µM.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Langat, MosesM.Langat@surrey.ac.uk
Helfenstein, A
Horner, C
Tammel, P
Hokkanen, H
Izotov, D
Mulholland, DulcieD.Mulholland@surrey.ac.uk
Date : October 2018
Funders : EU FP7
DOI : 10.1002/cbdv.201800056
Copyright Disclaimer : © 2018 Wiley‐VHCA AG, Zurich, Switzerland. This is the peer reviewed version of the following article: Moses K Langat, Andreas Helfenstein,Claire Horner, Päivi Tammela, Heikki Hokkanen, Denis Izotov, and Dulcie A Mulholland, (2018). Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae). DOI:10.1002/cbdv.201800056, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.201800056. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
Uncontrolled Keywords : Pinus pumila, pumilol, strobane, serratane triterpenoid, DP4+ probability, electronic circular dichroism
Depositing User : Melanie Hughes
Date Deposited : 04 Jul 2018 15:06
Last Modified : 04 Jul 2019 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/848655

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