University of Surrey

Test tubes in the lab Research in the ATI Dance Research

A study of experimental gastric ulcers and erosions.

MacDonald, Allan. (1976) A study of experimental gastric ulcers and erosions. Doctoral thesis, University of Surrey (United Kingdom)..

Available under License Creative Commons Attribution Non-commercial Share Alike.

Download (9MB) | Preview


Various models for an experimental study of gastric ulcers and erosions were sought and high incidences of erosion or ulceration were obtained using stress (Restraint), antiinflammatory drugs (phenylbutazone, aspirin), a corticosteroid (prednisolone) and physical or chemical trauma (electrocautery or acetic acid). Reproducible results were obtained only by carefully controlling variables such as sex, bodyweight, temperature and season. Histochemically,erosions and ulcers were associated with a loss of mucus, particularly from the regenerative zone of the mucosa. Biochemical studies after erosion formation confirmed the decrease in mucus content and also showed an altered carbohydrate composition of the mucus. Studies of mucous glycoprotein synthesis by measuring the rate of incorporation of labelled carbohydrate and amino acid suggested that one mode of action of stress and ulcerogenic drugs may be inhibition of the glycosylation of the mucus glycoprotein and hence a decreased synthesis of glycoprotein or the synthesis of a modified glycoprotein or both. Prostaglandins E[1], E[2] and F[2] were found to decrease the incorporation of carbohydrate and amino acid. This effect may be produced by stimulation of adenyl cyclase and elevation of cyclic AMP levels as the dibutyryl analogue of cyclic AMP and a phosphodiesterase inhibitor, theophylline were found to have similar effects. The dibutyryl analogue of cyclic GMP was found to have no effect on glycoprotein synthesis. Glycaemia was also found to be important as hypoglycaemia decreased glycoprotein synthesis and increased the susceptibility to erosion formation. It appears that a constant supply of glucose to the mucosal cells is necessary for synthesis of the mucus glycoprotein and normal cell function. The drug carbenoxolone sodium and an analogue cicloxolone sodium were shown to be effective against stress-induced erosions and also promoted the healing of electrocautery ulcers. The mechanism of action may be allied with increased mucus synthesis as both drugs were shown to increase the glycosylation of mucus glycoproteins.

Item Type: Thesis (Doctoral)
Divisions : Theses
Authors :
MacDonald, Allan.
Date : 1976
Contributors :
Additional Information : Thesis (Ph.D.)--University of Surrey (United Kingdom), 1976.
Depositing User : EPrints Services
Date Deposited : 22 Jun 2018 13:56
Last Modified : 06 Nov 2018 16:53

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800