University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Alphafoetoprotein and chemical carcinogenesis.

Lowing, R. K. (1977) Alphafoetoprotein and chemical carcinogenesis. Doctoral thesis, University of Surrey (United Kingdom)..

[img]
Preview
Text
10800325.pdf
Available under License Creative Commons Attribution Non-commercial Share Alike.

Download (8MB) | Preview

Abstract

The value of short term screening techniques for examining chemicals for their ability to cause cancer and the development of methods which facilitate the early detection of tumour growth is now widely accepted. The use of the quantitation of oncofoetal proteins has recently been proposed as a useful technique in both these fields of carcinogenesis. This thesis describes the development of a very sensitive radioimmunoassay for one such oncofoetal antigen, alphafoetoprotein, and examines the production of this protein during transplantation of tumour tissue and during treatment of cell cultures with carcinogens and non-carcinogens. A number of other parameters proposed as short-term screening procedures including DNA repair, increase in cell division, induction of biphenyl-2-hydroxylase activity and morphological changes are assessed and compared with the production of alphafoetoprotein. The role of alphafoetoprotein in stimulating cell growth and division is assessed along with its relationship to tumour immunology. The cell culture system is examined as an experimental model with which to study the effect of xenobiotics on animals and is compared to the commonly used technique of long-term parenteral administration of chemicals. The results obtained from these experiments are discussed in relation to the current literature in an attempt to rationalize a mechanism of tumour production.

Item Type: Thesis (Doctoral)
Divisions : Theses
Authors :
NameEmailORCID
Lowing, R. K.
Date : 1977
Contributors :
ContributionNameEmailORCID
http://www.loc.gov/loc.terms/relators/THS
Additional Information : Thesis (Ph.D.)--University of Surrey (United Kingdom), 1977.
Depositing User : EPrints Services
Date Deposited : 22 Jun 2018 13:56
Last Modified : 06 Nov 2018 16:53
URI: http://epubs.surrey.ac.uk/id/eprint/847658

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800