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Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation

Ossowski, P, Curatolo, A, Sampson, David and Munro, P (2018) Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation Biomedical Optics Express, 9 (7). pp. 3122-3136.

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Abstract

Realistic simulation of image formation in optical coherence tomography, based on Maxwell’s equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known, the microstructure of a scatterer significantly influences its scattering properties. Here we demonstrate that optimized scatterer design can overcome this problem resulting in good agreement between simulated and experimental images for a structured phantom. This approach to OCT image simulation allows for image formation for biological tissues to be simulated with unprecedented realism.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Ossowski, P
Curatolo, A
Sampson, Davidd.sampson@surrey.ac.uk
Munro, P
Date : 13 June 2018
DOI : 10.1364/BOE.9.003122
Copyright Disclaimer : Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
Depositing User : Melanie Hughes
Date Deposited : 19 Jun 2018 09:05
Last Modified : 04 Apr 2019 15:53
URI: http://epubs.surrey.ac.uk/id/eprint/847068

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