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Comparative analysis of adaptive immune responses following experimental infections of cattle with bovine viral diarrhoea virus-1 and an Asiatic atypical ruminant pestivirus

Riitho, Victor, Larska, Magdalena, Strong, Rebecca, La Rocca, Anna, Locker, Nicolas, Alenius, Stefan, Steinbach, Falko, Liu, Lihong, Uttenthal, Åse and Graham, Simon P. (2018) Comparative analysis of adaptive immune responses following experimental infections of cattle with bovine viral diarrhoea virus-1 and an Asiatic atypical ruminant pestivirus Vaccine, 36 (30). pp. 4494-4500.

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Abstract

Atypical ruminant pestiviruses are closely related to the two bovine viral diarrhoea virus (BVDV) species, BVDV-1 and BVDV-2. While there is evidence of cross-protective immune responses between BVDV-1 and BVDV-2, despite antigenic differences, there is little information on the antigenic cross-reactivity with atypical ruminant pestiviruses. The aim of this study was therefore to assess the specificity of antibody and T cell responses induced by experimental infection of calves with BVDV-1 strain Ho916, Th/04_KhonKaen (TKK), an Asiatic atypical ruminant pestivirus, or co-infection with both viruses. Homologous virus neutralization was observed in sera from both single virus infected and co-infected groups, while cross-neutralization was only observed in the TKK infected group. T cell IFN-γ responses to both viruses were observed in the TKK infected animals, whereas Ho916 infected calves responded better to homologous virus. Specifically, IFN-γ responses to viral non-structural protein, NS3, were observed in all infected groups while responses to viral glycoprotein, E2, were virus-specific. Broader antigen-specific cytokine responses were observed with similar trends between inoculation groups and virus species. The limited T cell and antibody immune reactivity of Ho916 inoculated animals to TKK suggests that animals vaccinated with current BVDV-1-based vaccines may not be protected against atypical ruminant pestiviruses.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Riitho, Victor
Larska, Magdalena
Strong, Rebecca
La Rocca, Anna
Locker, NicolasN.Locker@surrey.ac.uk
Alenius, Stefan
Steinbach, Falkof.steinbach@surrey.ac.uk
Liu, Lihong
Uttenthal, Åse
Graham, Simon P.s.graham@surrey.ac.uk
Date : 12 June 2018
DOI : 10.1016/j.vaccine.2018.06.019
Copyright Disclaimer : Crown Copyright © 2018 Published by Elsevier Ltd. All rights reserved.
Uncontrolled Keywords : BVDV; Atypical pestivirus; Immune responses; Cross-reactivity
Related URLs :
Depositing User : Clive Harris
Date Deposited : 07 Jun 2018 10:44
Last Modified : 05 Oct 2018 13:00
URI: http://epubs.surrey.ac.uk/id/eprint/847009

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