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Needle-probe system for the measurement of tissue refractive index

Zysk, A.M., Adie, S.G., Armstrong, J.J., Leigh, M.S., Paduch, A., Nguyen, F.T., Sampson, David and Boppart, S.A. (2007) Needle-probe system for the measurement of tissue refractive index

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Abstract

Needle-based devices, which are in wide clinical use for needle biopsy procedures, may be augmented by suitable optical techniques for the localization and diagnosis of diseased tissue. Tissue refractive index is one optical contrast mechanism with diagnostic potential. In the case of mammary tissue, for example, recent research indicates that refractive index variations between tissue types may be useful for the identification of cancerous tissue. While many coherence-based forward-sensing devices have been developed to detect scattering changes, none have demonstrated refractive index measurement capabilities. We present a novel needle-based device that is capable of simultaneously measuring refractive index and scattering. Coupled to the sample arm of an optical coherence tomography system, the needle device detects the scattering response and optical pathlength through tissue residing in a fixed-width channel. Near-infrared measurements of tissues and materials with known optical properties using a prototype device will be presented. This work demonstrates the feasibility of integrated in vivo measurement of refractive index and scattering in conjunction with existing clinical needle-based devices.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Zysk, A.M.
Adie, S.G.
Armstrong, J.J.
Leigh, M.S.
Paduch, A.
Nguyen, F.T.
Sampson, Davidd.sampson@surrey.ac.uk
Boppart, S.A.
Date : 2007
DOI : 10.1117/12.700955
Uncontrolled Keywords : Fiber optic devices, Low coherence interferometry, Optical coherence tomography, Refractive index, Light scattering, Measurement theory, Optical tomography, Refractive index, Tissue, Fiber optic devices, Fixed-width channel, Low coherence interferometry, Biomedical engineering
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 11 Jun 2018 08:39
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846900

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