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Mapping tissue optical attenuation to identify cancer using optical coherence tomography

McLaughlin, R.A., Scolaro, L., Robbins, P., Saunders, C., Jacques, S.L. and Sampson, David (2009) Mapping tissue optical attenuation to identify cancer using optical coherence tomography .

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The lymphatic system is a common route for the spread of cancer and the identification of lymph node metastases is a key task during cancer surgery. This paper demonstrates the use of optical coherence tomography to construct parametric images of lymph nodes. It describes a method to automatically estimate the optical attenuation coefficient of tissue. By mapping the optical attenuation coefficient at each location in the scan, it is possible to construct a parametric image indicating variations in tissue type. The algorithm is applied to ex vivo samples of human axillary lymph nodes and validated against a histological gold standard. Results are shown illustrating the variation in optical properties between cancerous and healthy tissue.

Item Type: Other
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
McLaughlin, R.A.
Scolaro, L.
Robbins, P.
Saunders, C.
Jacques, S.L.
Date : 2009
DOI : 10.1007/978-3-642-04271-3_80
Uncontrolled Keywords : Axillary lymph nodes, Ex-vivo, Gold standards, Healthy tissues, Lymph node, Lymph node metastasis, Lymphatic systems, Optical attenuation, Optical coherence Tomography, Parametric image, Tissue types, Body fluids, Coherent light, Electromagnetic wave attenuation, Medical computing, Tomography, Optical properties
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 11 Jun 2018 07:17
Last Modified : 06 Jul 2019 05:25

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