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Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography

Williamson, J.P., Armstrong, J.J., McLaughlin, R.A., Noble, P.B., West, A.R., Becker, S., Curatolo, A., Noffsinger, W.J., Mitchell, H.W., Phillips, M.J. , Sampson, D.D., Hillman, D.R. and Eastwood, P.R. (2010) Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography European Respiratory Journal, 35 (1). pp. 34-41.

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Abstract

Airway dimensions are difficult to quantify bronchoscopically because of optical distortion and a limited ability to gauge depth. Anatomical optical coherence tomography (aOCT), a novel imaging technique, may overcome these limitations. This study evaluated the accuracy of aOCT against existing techniques in phantom, excised pig and in vivo human airways. Three comparative studies were performed: 1) micrometer-derived area measurements in 10 plastic tubes were compared with aOCT-derived area; 2) aOCT-derived airway compliance curves from excised pig airways were compared with curves derived using an endoscopic technique; and 3) airway dimensions from the trachea to subsegmental bronchi were measured using aOCT in four anaesthetised patients during bronchoscopy and compared with computed tomography (CT) measurements. Measurements in plastic tubes revealed aOCT to be accurate and reliable. In pig airways, aOCT-derived compliance measurements compared closely with endoscopic data. In human airways, dimensions measured with aOCT and CT correlated closely. Bland - Altman plots showed that aOCT diameter and area measurements were higher than CT measurements by 7.6% and 15.1%, respectively. Airway measurements using aOCT are accurate, reliable and compare favourably with existing imaging techniques. Using aOCT with conventional bronchoscopy allows real-time measurement of airway dimensions and could be useful clinically in settings where knowledge of airway calibre is required.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Williamson, J.P.
Armstrong, J.J.
McLaughlin, R.A.
Noble, P.B.
West, A.R.
Becker, S.
Curatolo, A.
Noffsinger, W.J.
Mitchell, H.W.
Phillips, M.J.
Sampson, D.D.d.sampson@surrey.ac.uk
Hillman, D.R.
Eastwood, P.R.
Date : 2010
DOI : 10.1183/09031936.00041809
Uncontrolled Keywords : Airway dimensions, Computed tomography, Interventional bronchoscopy, Optical coherence tomography, Quantitative bronchoscopy, anesthesia, animal experiment, animal tissue, article, bronchoscopy, bronchus, comparative study, computed tomography scanner, computer assisted tomography, controlled study, diagnostic accuracy, diagnostic imaging, endoscopy, functional residual capacity, human, impedance plethysmography, in vivo study, lung clearance, nonhuman, optical coherence tomography, priority journal, swine, trachea, tracheobronchial tree, videoendoscopy, Animals, Bronchi, Bronchoscopy, Humans, Organ Size, Swine, Tomography, Optical Coherence, Trachea
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 06 Jun 2018 11:36
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846874

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