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Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer

McLaughlin, R.A., Scolaro, L., Robbins, P., Hamza, S., Saunders, C. and Sampson, D.D. (2010) Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer Cancer Research, 70 (7). pp. 2579-2584.

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Histologic assessment is the gold standard technique for the identification of metastatic involvement of lymph nodes in malignant disease, but can only be performed ex vivo and often results in the unnecessary excision of healthy lymph nodes, leading to complications such as lymphedema. Optical coherence tomogra-phy (OCT) is a high-resolution, near-IR imaging modality capable of visualizing microscopic features within tissue. OCT has the potential to provide in vivo assessment of tissue involvement by cancer. In this morpho-logic study, we show the capability of OCT to image nodal microarchitecture through an assessment of fresh, unstained ex vivo lymph node samples. Examples include both benign human axillary lymph nodes and nodes containing metastatic breast carcinoma. Through accurate correlation with the histologic gold standard, OCT is shown to enable differentiation of lymph node tissue from surrounding adipose tissue, reveal nodal struc-tures such as germinal centers and intranodal vessels, and show both diffuse and well circumscribed patterns of metastatic node involvement.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
McLaughlin, R.A.
Scolaro, L.
Robbins, P.
Hamza, S.
Saunders, C.
Date : 2010
DOI : 10.1158/0008-5472.CAN-09-4062
Uncontrolled Keywords : adipose tissue, article, axillary lymph node, benign tumor, breast carcinoma, cancer staging, clinical article, controlled study, germinal center, histopathology, human, human tissue, invasive carcinoma, lymph node metastasis, lymph vessel, lymphography, optical coherence tomography, priority journal, sentinel lymph node, stroma, Breast Neoplasms, Carcinoma, Ductal, Breast, Female, Humans, Lymph Nodes, Lymphatic Metastasis, Neoplasm Staging, Neoplasms, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 06 Jun 2018 11:29
Last Modified : 19 Sep 2018 11:32

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