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Measurement, reconstruction, and flow-field computation of the human pharynx with application to sleep apnea

Lucey, A.D., King, A.J.C., Tetlow, G.A., Wang, J., Armstrong, J.J., Leigh, M.S., Paduch, A., Walsh, J.H., Sampson, D.D., Eastwood, P.R. and Hillman, D.R. (2010) Measurement, reconstruction, and flow-field computation of the human pharynx with application to sleep apnea IEEE Transactions on Biomedical Engineering, 57 (10 PAR). pp. 2535-2548.

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Abstract

Repetitive closure of the upper airway characterizes obstructive sleep apnea. It disrupts sleep causing excessive daytime drowsiness and is linked to hypertension and cardiovascular disease. Previous studies simulating the underlying fluid mechanics are based upon geometries, time-averaged over the respiratory cycle, obtained usually via MRI or CT scans. Here, we generate an anatomically correct geometry from data captured in vivo by an endoscopic optical technique. This allows quantitative real-time imaging of the internal cross section with minimal invasiveness. The steady inhalation flow field is computed using a k- shear-stress transport (SST) turbulence model. Simulations reveal flow mechanisms that produce low-pressure regions on the sidewalls of the pharynx and on the soft palate within the pharyngeal section of minimum area. Soft-palate displacement and side-wall deformations further reduce the pressures in these regions, thus creating forces that would tend to narrow the airway. These phenomena suggest a mechanism for airway closure in the lateral direction as clinically observed. Correlations between pressure and airway deformation indicate that quantitative prediction of the low-pressure regions for an individual are possible. The present predictions warrant and can guide clinical investigation to confirm the phenomenology and its quantification, while the overall approach represents an advancement toward patient-specific modeling.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Lucey, A.D.
King, A.J.C.
Tetlow, G.A.
Wang, J.
Armstrong, J.J.
Leigh, M.S.
Paduch, A.
Walsh, J.H.
Sampson, D.D.d.sampson@surrey.ac.uk
Eastwood, P.R.
Hillman, D.R.
Date : 2010
DOI : 10.1109/TBME.2010.2052808
Uncontrolled Keywords : Computational fluid dynamics, Image processing, Optical coherence tomography (OCT), Sleep apnea, Upper airway anatomy, Airway closure, Cardio-vascular disease, Clinical investigation, Cross section, CT scan, Flow mechanisms, In-vivo, Invasiveness, Lateral directions, Obstructive sleep apnea, Optical coherence tomography, Optical technique, Patient-specific modeling, Pressure regions, Quantitative prediction, Realtime imaging, Respiratory cycle, Shear-stress transport, Side walls, Sleep apnea, Soft palates, Time-averaged, Upper airway, Coherent light, Computational fluid dynamics, Contacts (fluid mechanics), Deformation, Fluid dynamics, Fluids, Image processing, Imaging systems, Optical data processing, Respiratory mechanics, Sleep research, Turbulence models, Computerized tomography, airway dynamics, article, inhalation, measurement, pharynx, shear stress, simulation, sleep apnea syndrome, soft palate, Endoscopy, Humans, Image Processing, Computer-Assisted, Models, Biological, Palate, Soft, Pharynx, Sleep Apnea Syndromes, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 06 Jun 2018 11:25
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846864

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