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In situ imaging of lung alveoli with an optical coherence tomography needle probe

Quirk, B.C., McLaughlin, R.A., Curatolo, A., Kirk, R.W., Noble, P.B. and Sampson, D.D. (2011) In situ imaging of lung alveoli with an optical coherence tomography needle probe Journal of Biomedical Optics, 16 (3).

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Abstract

In situ imaging of alveoli and the smaller airways with optical coherence tomography (OCT) has significant potential in the assessment of lung disease. We present a minimally invasive imaging technique utilizing an OCT needle probe. The side-facing needle probe comprises miniaturized focusing optics consisting of no-core and GRIN fiber encased within a 23-gauge needle. 3D-OCT volumetric data sets were acquired by rotating and retracting the probe during imaging. The probe was used to image an intact, fresh (not fixed) sheep lung filled with normal saline, and the results validated against a histological gold standard. We present the first published images of alveoli acquired with an OCT needle probe and demonstrate the potential of this technique to visualize other anatomical features such as bifurcations of the bronchioles.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Quirk, B.C.
McLaughlin, R.A.
Curatolo, A.
Kirk, R.W.
Noble, P.B.
Sampson, D.D.d.sampson@surrey.ac.uk
Date : 2011
DOI : 10.1117/1.3556719
Uncontrolled Keywords : Alveoli, Interstitial, Lungs, Optical coherence tomography, Optical needle probe, Pulmonary imaging, Alveoli, Interstitial, Lungs, Optical needle probe, Pulmonary imaging, Biological organs, Needles, Tomography, Volumetric analysis, Probes, Ovis aries
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 06 Jun 2018 10:58
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846855

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