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In vivo three-dimensional optical coherence elastography

Kennedy, B.F., Liang, X., Adie, S.G., Gerstmann, D.K., Quirk, B.C., Boppart, S.A. and Sampson, D.D. (2011) In vivo three-dimensional optical coherence elastography Optics Express, 19 (7). pp. 6623-6634.

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Abstract

We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Kennedy, B.F.
Liang, X.
Adie, S.G.
Gerstmann, D.K.
Quirk, B.C.
Boppart, S.A.
Sampson, D.D.d.sampson@surrey.ac.uk
Date : 2011
DOI : 10.1364/OE.19.006623
Uncontrolled Keywords : Coherent light, Hydration, Strain rate, Tomography, Data sets, Elastic response, Human skin in vivo, In-vivo, Line rate, Mechanical excitations, Optical coherence elastography, Preloads, Ring actuators, Spectral-domain optical coherence tomography, Stratum corneum, Three-dimensional (3D), Uni-axial strains, Three dimensional, article, echography, elastography, epiluminescence microscopy, equipment, equipment design, functions of the skin and its appendages, human, image enhancement, instrumentation, optical coherence tomography, reproducibility, sensitivity and specificity, skin, Dermoscopy, Elasticity Imaging Techniques, Equipment Design, Equipment Failure Analysis, Humans, Image Enhancement, Reproducibility of Results, Sensitivity and Specificity, Skin, Skin Physiological Phenomena, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 15:30
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846854

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