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In situ 3D imaging of alveoli with a 30 gauge side-facing optical needle probe

Yang, X., McLaughlin, R.A., Lorenser, D., Kirk, R.W., Noble, P.B. and Sampson, D.D. (2011) In situ 3D imaging of alveoli with a 30 gauge side-facing optical needle probe

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In situ imaging of alveoli and small airways with optical coherence tomography (OCT) needle probes has significant potential in the study and clinical assessment of lung disease. We present the smallest reported OCT needle probe capable of acquiring 3D volumetric data. The side-facing needle probe comprises miniaturized focusing optics consisting of no-core and GRIN fibre, terminated with a reflection-coated, fibre tip beam deflector. The optics are encased within a 30-gauge (outer diameter 310 m) needle, and interfaced to a spectral-domain OCT scanner. Multiple 3D-OCT data sets were acquired on preterm lamb lungs (excised) filled with amniotic fluid and saline. Results demonstrated the ability of such a probe to image individual alveoli and bronchioles, and enabled the rendering of 3D volumetric visualisations of the data. We observed notably less tissue distortion than in earlier work with larger 23 gauge needle probes.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Yang, X.
McLaughlin, R.A.
Lorenser, D.
Kirk, R.W.
Noble, P.B.
Date : 2011
DOI : 10.1109/ISSNIP.2011.6146625
Uncontrolled Keywords : 3D imaging, Amniotic fluid, Beam deflectors, Clinical assessments, Data sets, Fibre tip, Focusing optics, In-situ, Needle probes, Outer diameters, Small airways, Spectral-domain, Volumetric data, Data processing, Gages, Intelligent control, Needles, Optical tomography, Probes, Sensor networks, Smart sensors, Three dimensional computer graphics, Tissue, Visualization, Volumetric analysis, Three dimensional
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 06 Jun 2018 11:05
Last Modified : 19 Sep 2018 11:32

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