University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Parametric imaging of the local attenuation coefficient in human axillary lymph nodes assessed using optical coherence tomography

Scolaro, L., McLaughlin, R.A., Klyen, B.R., Wood, B.A., Robbins, P.D., Saunders, C.M., Jacques, S.L. and Sampson, D.D. (2012) Parametric imaging of the local attenuation coefficient in human axillary lymph nodes assessed using optical coherence tomography Biomedical Optics Express, 3 (2). pp. 366-379.

Full text not available from this repository.

Abstract

We report the use of optical coherence tomography (OCT) to determine spatially localized optical attenuation coefficients of human axillary lymph nodes and their use to generate parametric images of lymphoid tissue. 3D-OCT images were obtained from excised lymph nodes and optical attenuation coefficients were extracted assuming a single scattering model of OCT. We present the measured attenuation coefficients for several tissue regions in benign and reactive lymph nodes, as identified by histopathology. We show parametric images of the measured attenuation coefficients as well as segmented images of tissue type based on thresholding of the attenuation coefficient values. Comparison to histology demonstrates the enhancement of contrast in parametric images relative to OCT images. This enhancement is a step towards the use of OCT for in situ assessment of lymph nodes.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Scolaro, L.
McLaughlin, R.A.
Klyen, B.R.
Wood, B.A.
Robbins, P.D.
Saunders, C.M.
Jacques, S.L.
Sampson, D.D.d.sampson@surrey.ac.uk
Date : 2012
DOI : 10.1364/BOE.3.000366
Uncontrolled Keywords : Body fluids, Electromagnetic wave attenuation, Tissue, Tomography, Attenuation coefficient, Axillary lymph nodes, In-situ assessment, Optical attenuation, Parametric image, Parametric imaging, Segmented images, Single-scattering model, Optical tomography
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 15:19
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846842

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800