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Strain estimation in phase-sensitive optical coherence elastography

Kennedy, B.F., Koh, S.H., McLaughlin, R.A., Kennedy, K.M., Munro, P.R.T. and Sampson, D.D. (2012) Strain estimation in phase-sensitive optical coherence elastography Biomedical Optics Express, 3 (8). pp. 1865-1879.

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We present a theoretical framework for strain estimation in optical coherence elastography (OCE), based on a statistical analysis of displacement measurements obtained from a mechanically loaded sample. We define strain sensitivity, signal-to-noise ratio and dynamic range, and derive estimates of strain using three methods: finite difference, ordinary least squares and weighted least squares, the latter implemented for the first time in OCE. We compare theoretical predictions with experimental results and demonstrate a ~12 dB improvement in strain sensitivity using weighted least squares compared to finite difference strain estimation and a ~4 dB improvement over ordinary least squares strain estimation. We present strain images (i.e., elastograms) of tissue-mimicking phantoms and excised porcine airway, demonstrating in each case clear contrast based on the sample's elasticity.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Kennedy, B.F.
Koh, S.H.
McLaughlin, R.A.
Kennedy, K.M.
Munro, P.R.T.
Date : 2012
DOI : 10.1364/BOE.3.001865
Uncontrolled Keywords : Elasticity, Least squares approximations, Tissue, Dynamic range, Elastograms, Finite difference, Optical coherence elastography, Ordinary least squares, Phase-sensitive, Strain estimation, Strain images, Strain sensitivity, Theoretical framework, Theoretical prediction, Tissue mimicking phantom, Weighted least squares, Estimation, Sus
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 14:24
Last Modified : 19 Sep 2018 11:32

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