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Motion correction of in vivo three-dimensional optical coherence tomography of human skin using a fiducial marker

Liew, Y.M., McLaughlin, R.A., Wood, F.M. and Sampson, D.D. (2012) Motion correction of in vivo three-dimensional optical coherence tomography of human skin using a fiducial marker Biomedical Optics Express, 3 (8). pp. 1774-1786.

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This paper presents a novel method based on a fiducial marker for correction of motion artifacts in 3D, in vivo, optical coherence tomography (OCT) scans of human skin and skin scars. The efficacy of this method was compared against a standard cross-correlation intensity-based registration method. With a fiducial marker adhered to the skin, OCT scans were acquired using two imaging protocols: direct imaging from air into tissue; and imaging through ultrasound gel into tissue, which minimized the refractive index mismatch at the tissue surface. The registration methods were assessed with data from both imaging protocols and showed reduced distortion of skin features due to motion. The fiducial-based method was found to be more accurate and robust, with an average RMS error below 20 μm and success rate above 90%. In contrast, the intensity-based method had an average RMS error ranging from 36 to 45 μm, and a success rate from 50% to 86%. The intensity-based algorithm was found to be particularly confounded by corrugations in the skin. By contrast, tissue features did not affect the fiducial-based method, as the motion correction was based on delineation of the flat fiducial marker. The average computation time for the fiducial-based algorithm was approximately 21 times less than for the intensity-based algorithm.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Liew, Y.M.
McLaughlin, R.A.
Wood, F.M.
Date : 2012
DOI : 10.1364/BOE.3.001774
Uncontrolled Keywords : Algorithms, Three dimensional, Tissue, Computation time, Cross correlations, Direct imaging, Fiducial marker, Human skin, Imaging protocol, In-vivo, Intensity-based, Intensity-based methods, Intensity-based registration, Motion artifact, Motion correction, Refractive index mismatch, Registration methods, RMS errors, Tissue surface, Optical tomography
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 14:58
Last Modified : 19 Sep 2018 11:32

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