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Improved measurement of vibration amplitude in dynamic optical coherence elastography

Kennedy, B.F., Wojtkowski, M., Szkulmowski, M., Kennedy, K.M., Karnowski, K. and Sampson, D.D. (2012) Improved measurement of vibration amplitude in dynamic optical coherence elastography Biomedical Optics Express, 3 (12). pp. 3138-3152.

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Abstract

Optical coherence elastography employs optical coherence tomography (OCT) to measure the displacement of tissues under load and, thus, maps the resulting strain into an image, known as an elastogram. We present a new improved method to measure vibration amplitude in dynamic optical coherence elastography. The tissue vibration amplitude caused by sinusoidal loading is measured from the spread of the Doppler spectrum, which is extracted using joint spectral and time domain signal processing. At low OCT signal-to-noise ratio (SNR), the method provides more accurate vibration amplitude measurements than the currently used phasesensitive method. For measurements performed on a mirror at OCT SNR = 5 dB, our method introduces <3% error, compared to >20% using the phasesensitive method. We present elastograms of a tissue-mimicking phantom and excised porcine tissue that demonstrate improvements, including a 50% increase in the depth range of reliable vibration amplitude measurement.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Kennedy, B.F.
Wojtkowski, M.
Szkulmowski, M.
Kennedy, K.M.
Karnowski, K.
Sampson, D.D.d.sampson@surrey.ac.uk
Date : 2012
DOI : 10.1364/BOE.3.003138
Uncontrolled Keywords : Loading, Signal processing, Tissue, Vibration measurement, Depth range, Doppler spectra, Elastograms, Optical coherence elastography, Phase-sensitive methods, Signaltonoise ratio (SNR), Sinusoidal loading, Time-domain signal, Tissue mimicking phantom, Tissue vibrations, Vibration amplitude, Optical tomography
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 14:29
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846830

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