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En face parametric imaging of tissue birefringence using polarization-sensitive optical coherence tomography

Chin, L., Yang, X., McLaughlin, R.A., Noble, P.B. and Sampson, David (2013) En face parametric imaging of tissue birefringence using polarization-sensitive optical coherence tomography Journal of Biomedical Optics, 18 (6).

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Abstract

A technique for generating en face parametric images of tissue birefringence from scans acquired using a fiber-based polarization-sensitive optical coherence tomography (PS-OCT) system utilizing only a single-incident polarization state is presented. The value of birefringence is calculated for each A-scan in the PS-OCT volume using a quadrature demodulation and phase unwrapping algorithm. The algorithm additionally uses weighted spatial averaging and weighted least squares regression to account for the variation in phase accuracies due to varying OCT signal-to-noise-ratio. The utility of this technique is demonstrated using a model of thermally induced damage in porcine tendon and validated against histology. The resulting en face images of tissue birefringence are more useful than conventional PS-OCT B-scans in assessing the severity of tissue damage and in localizing the spatial extent of damage.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Chin, L.
Yang, X.
McLaughlin, R.A.
Noble, P.B.
Sampson, Davidd.sampson@surrey.ac.uk
Date : 2013
DOI : 10.1117/1.JBO.18.6.066005
Uncontrolled Keywords : optical coherence tomography, parametric imaging, polarization, tissue birefringence, Parametric imaging, Phase unwrapping algorithm, Polarization sensitive optical coherence tomography, Polarization state, Quadrature demodulation, Thermally induced, Tissue birefringence, Weighted least squares, Algorithms, Capillary flow, Optical tomography, Polarization, Tissue, Birefringence, collagen, algorithm, animal, article, artifact, automation, birefringence, chemistry, equipment, equipment design, image processing, methodology, optical coherence tomography, pathology, polarization microscopy, signal noise ratio, swine, tendon, devices, image processing, optical coherence tomography, pathology, polarization microscopy, procedures, tendon, Algorithms, Animals, Artifacts, Automation, Birefringence, Collagen, Equipment Design, Image Processing, Computer-Assisted, Microscopy, Polarization, Signal-To-Noise Ratio, Swine, Tendons, Tomography, Optical Coherence, Algorithms, Animals, Artifacts, Automation, Birefringence, Collagen, Equipment Design, Image Processing, Computer-Assisted, Microscopy, Polarization, Signal-To-Noise Ratio, Swine, Tendons, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 09:32
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846819

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