University of Surrey

Test tubes in the lab Research in the ATI Dance Research

In vivo assessment of human burn scars through automated quantification of vascularity using optical coherence tomography

Liew, Y.M., McLaughlin, R.A., Gong, P., Wood, F.M. and Sampson, David (2013) In vivo assessment of human burn scars through automated quantification of vascularity using optical coherence tomography Journal of Biomedical Optics, 18 (6).

Full text not available from this repository.


In scars arising from burns, objective assessment of vascularity is important in the early identification of pathological scarring, and in the assessment of progression and treatment response. We demonstrate the first clinical assessment and automated quantification of vascularity in cutaneous burn scars of human patients in vivo that uses optical coherence tomography (OCT). Scar microvasculature was delineated in three-dimensional OCT images using speckle decorrelation. The diameter and area density of blood vessels were automatically quantified. A substantial increase was observed in the measured density of vasculature in hypertrophic scar tissues (38%) when compared against normal, unscarred skin (22%). A proliferation of larger vessels (diameter≥100  μm) was revealed in hypertrophic scarring, which was absent from normal scars and normal skin over the investigated physical depth range of 600 μm. This study establishes the feasibility of this methodology as a means of clinical monitoring of scar progression.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Liew, Y.M.
McLaughlin, R.A.
Gong, P.
Wood, F.M.
Date : 2013
DOI : 10.1117/1.JBO.18.6.061213
Uncontrolled Keywords : in vivo imaging, optical coherence tomography, scar assessment, skin, speckle decorrelation, vascularity, vasculature, In-Vivo imaging, scar assessment, Speckle decorrelation, vascularity, Vasculature, Blood vessels, Skin, Speckle, Optical tomography, adult, article, burn, chemistry, female, human, hypertrophic scar, male, methodology, microvasculature, optical coherence tomography, pathology, skin, three dimensional imaging, vascularization, Adult, Burns, Cicatrix, Hypertrophic, Female, Humans, Imaging, Three-Dimensional, Male, Microvessels, Skin, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 09:42
Last Modified : 19 Sep 2018 11:32

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800