Effect of the velopharynx on intraluminal pressures in reconstructed pharynges derived from individuals with and without sleep apnea
Cisonni, J., Lucey, A.D., Walsh, J.H., King, A.J.C., Elliott, N.S.J., Sampson, David, Eastwood, P.R. and Hillman, D.R. (2013) Effect of the velopharynx on intraluminal pressures in reconstructed pharynges derived from individuals with and without sleep apnea Journal of Biomechanics, 46 (14). pp. 2504-2512.
Full text not available from this repository.Abstract
The most collapsible part of the upper airway in the majority of individuals is the velopharynx which is the segment positioned behind the soft palate. As such it is an important morphological region for consideration in elucidating the pathogenesis of obstructive sleep apnea (OSA). This study compared steady flow properties during inspiration in the pharynges of nine male subjects with OSA and nine body-mass index (BMI)- and age-matched control male subjects without OSA. The k– SST turbulence model was used to simulate the flow field in subject-specific pharyngeal geometric models reconstructed from anatomical optical coherence tomography (aOCT) data. While analysis of the geometry of reconstructed pharynges revealed narrowing at velopharyngeal level in subjects with OSA, it was not possible to clearly distinguish them from subjects without OSA on the basis of pharyngeal size and shape alone. By contrast, flow simulations demonstrated that pressure fields within the narrowed airway segments were sensitive to small differences in geometry and could lead to significantly different intraluminal pressure characteristics between subjects. The ratio between velopharyngeal and total pharyngeal pressure drops emerged as a relevant flow-based criterion by which subjects with OSA could be differentiated from those without.
Item Type: | Article | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Divisions : |
Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences |
|||||||||||||||||||||||||||
Authors : |
|
|||||||||||||||||||||||||||
Date : | 2013 | |||||||||||||||||||||||||||
DOI : | 10.1016/j.jbiomech.2013.07.007 | |||||||||||||||||||||||||||
Uncontrolled Keywords : | Airway resistance, CFD, Obstructive sleep apnea, Pharyngeal wall pressure, Velopharynx, Age-matched controls, Geometric models, Intraluminal pressure, Obstructive sleep apnea, SST turbulence models, Subject-specific, Velopharynx, Wall pressure, Blood vessels, Computational fluid dynamics, Optical tomography, Sleep research, age distribution, airway pressure, anatomic landmark, apnea hypopnea index, article, body mass, breathing pattern, clinical article, controlled study, flow kinetics, human, human tissue, image reconstruction, inspiratory capacity, male, mathematical model, optical coherence tomography, pathological anatomy, pharynx reconstruction, priority journal, respiratory airflow, sleep disordered breathing, surgical anatomy, velopharyngeal sphincter, Airway resistance, CFD, Obstructive sleep apnea, Pharyngeal wall pressure, Velopharynx, Adult, Aged, Humans, Male, Middle Aged, Models, Biological, Pharynx, Pressure, Pulmonary Ventilation, Sleep Apnea, Obstructive | |||||||||||||||||||||||||||
Depositing User : | Maria Rodriguez-Marquez | |||||||||||||||||||||||||||
Date Deposited : | 05 Jun 2018 09:35 | |||||||||||||||||||||||||||
Last Modified : | 19 Sep 2018 11:32 | |||||||||||||||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/846813 |
Actions (login required)
![]() |
View Item |
Downloads
Downloads per month over past year