Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues
Kennedy, K.M., McLaughlin, R.A., Kennedy, B.F., Tien, A., Latham, B., Saunders, C.M. and Sampson, David (2013) Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues Journal of Biomedical Optics, 18 (12).
Full text not available from this repository.Abstract
Optical coherence elastography (OCE) is an emerging imaging technique that probes microscale mechanical contrast in tissues with the potential to differentiate healthy and malignant tissues. However, conventional OCE techniques are limited to imaging the first 1 to 2 mmof tissue in depth. We demonstrate, for the first time, OCE measurements deep within human tissues using needle OCE, extending the potential of OCE as a surgical guidance tool. We use needle OCE to detect tissue interfaces based on mechanical contrast in both normal and malignant breast tissues in freshly excised human mastectomy samples, as validated against histopathology. Further, we demonstrate the feasibility of in situ measurements 4 cm from the tissue surface using ultrasound guidance of the OCE needle probe. With further refinement, our method may potentially aid in accurate detection of the boundary of the tumor to help ensure full removal of all malignant tissues, which is critical to the success of breast-conserving surgery.
Item Type: | Article | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Divisions : |
Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences |
||||||||||||||||||||||||
Authors : |
|
||||||||||||||||||||||||
Date : | 2013 | ||||||||||||||||||||||||
DOI : | 10.1117/1.JBO.18.12.121510 | ||||||||||||||||||||||||
Uncontrolled Keywords : | breast cancer, elastography, mechanical properties, needle probe, optical coherence tomography, Breast Cancer, Breast conserving surgery, Elastography, Human breast tissue, In-situ measurement, Needle probes, Optical coherence elastography, Ultrasound guidance, Biomechanics, Histology, Mechanical properties, Medical imaging, Needles, Optical tomography, Probes, Surgery, Tissue, article, biomechanics, breast, breast tumor, cytochemistry, equipment, female, human, methodology, needle, optical coherence tomography, pathology, reproducibility, Biomechanical Phenomena, Breast, Breast Neoplasms, Female, Histocytochemistry, Humans, Needles, Reproducibility of Results, Tomography, Optical Coherence | ||||||||||||||||||||||||
Depositing User : | Maria Rodriguez-Marquez | ||||||||||||||||||||||||
Date Deposited : | 05 Jun 2018 09:39 | ||||||||||||||||||||||||
Last Modified : | 19 Sep 2018 11:32 | ||||||||||||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/846809 |
Actions (login required)
![]() |
View Item |
Downloads
Downloads per month over past year