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Assessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking

Gong, P., McLaughlin, R.A., Liew, Y.M., Munro, P.R.T., Wood, F.M. and Sampson, David (2014) Assessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking Journal of Biomedical Optics, 19 (2).

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Abstract

The formation of burn-scar tissue in human skin profoundly alters, among other things, the structure of the dermis. We present a method to characterize dermal scar tissue by the measurement of the near-infrared attenuation coefficient using optical coherence tomography (OCT). To generate accurate en face parametric images of attenuation, we found it critical to first identify (using speckle decorrelation) and mask the tissue vasculature from the three-dimensional OCT data. The resulting attenuation coefficients in the vasculature-masked regions of the dermis of human burn-scar patients are lower in hypertrophic (3.8±0.4 mm-1) and normotrophic (4.2±0.9 mm-1) scars than in contralateral or adjacent normal skin (6.3±0.5 mm-1). Our results suggest that the attenuation coefficient of vasculature-masked tissue could be used as an objective means to assess human burn scars.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Gong, P.
McLaughlin, R.A.
Liew, Y.M.
Munro, P.R.T.
Wood, F.M.
Sampson, Davidd.sampson@surrey.ac.uk
Date : 2014
DOI : 10.1117/1.JBO.19.2.021111
Uncontrolled Keywords : attenuation coefficient, burn scars, collagen, hypertrophic scars, optical coherence tomography, parametric imaging, scar assessment, vasculature, Attenuation coefficient, Burn scar, Hypertrophic scar, Parametric imaging, scar assessment, Vasculature, Collagen, Optical tomography, Tissue, adult, article, burn, female, human, image processing, male, methodology, middle aged, optical coherence tomography, pathology, scar, skin, vascularization, young adult, Adult, Burns, Cicatrix, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Skin, Tomography, Optical Coherence, Young Adult
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 08:55
Last Modified : 19 Sep 2018 11:32
URI: http://epubs.surrey.ac.uk/id/eprint/846803

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