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Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans

Kennedy, B.F., Malheiro, F.G., Chin, L. and Sampson, David (2014) Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans Journal of Biomedical Optics, 19 (7).

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We present an acquisition method for optical coherence elastography (OCE) that enables acquisition of three-dimensional elastograms in 5 s, an order of magnitude faster than previously reported. In this method, based on compression elastography, the mechanical load applied to the sample is altered between acquisitions of consecutive optical coherence tomography volume scans (C-scans). The voxel-by-voxel phase difference between the volumes is used to determine the axial displacement and determining the gradient of the axial displacement versus depth gives the local axial strain. We demonstrate sub-100-microstrain sensitivity and high contrast in elastograms, acquired in 5 s, of structured phantoms and freshly excised rat muscle tissue that are comparable in strain sensitivity and dynamic range to our previously reported B-scan-based method. The much higher acquisition speed may expedite the translation of OCE to clinical and in vivo applications

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Kennedy, B.F.
Malheiro, F.G.
Chin, L.
Date : 2014
DOI : 10.1117/1.JBO.19.7.076006
Uncontrolled Keywords : biomechanics, optical coherence elastography, optical coherence tomography, strain, Biomechanics, Medical imaging, Optical tomography, Strain, Axial displacements, High contrast, Mechanical loads, Muscle tissues, Optical coherence elastography, Phase difference, Phase-sensitive, Strain sensitivity, Mergers and acquisitions, anatomy and histology, animal, elastography, image quality, optical coherence tomography, procedures, rat, skeletal muscle, three dimensional imaging, anatomy and histology, Animals, Elasticity Imaging Techniques, Imaging, Three-Dimensional, methods, methods, methods, Muscle, Skeletal, Phantoms, Imaging, Rats, Tomography, Optical Coherence
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 09:02
Last Modified : 19 Sep 2018 11:32

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