Optical coherence tomography can assess skeletal muscle tissue from mouse models of muscular dystrophy by parametric imaging of the attenuation coefficient

Klyen, B.R., Scolaro, L., Shavlakadze, T., Grounds, M.D. and Sampson, David (2014) Optical coherence tomography can assess skeletal muscle tissue from mouse models of muscular dystrophy by parametric imaging of the attenuation coefficient Biomedical Optics Express, 5 (4). pp. 1217-1232.

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Abstract

We present the assessment of ex vivo mouse muscle tissue by quantitative parametric imaging of the near-infrared attenuation coefficient μt using optical coherence tomography. The resulting values of the local total attenuation coefficient μt (mean ± standard error) from necrotic lesions in the dystrophic skeletal muscle tissue of mdx mice are higher (9.6 ± 0.3 mm-1) than regions from the same tissue containing only necrotic myofibers (7.0 ± 0.6 mm-1), and significantly higher than values from intact myofibers, whether from an adjacent region of the same sample (4.8 ± 0.3 mm-1) or from healthy tissue of the wild-type C57 mouse (3.9 ± 0.2 mm-1) used as a control. Our results suggest that the attenuation coefficient could be used as a quantitative means to identify necrotic lesions and assess skeletal muscle tissue in mouse models of human Duchenne muscular dystrophy.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences
Authors :	Name Email ORCID Klyen, B.R. Scolaro, L. Shavlakadze, T. Grounds, M.D. Sampson, David d.sampson@surrey.ac.uk
Date :	2014
DOI :	10.1364/BOE.5.001217
Uncontrolled Keywords :	Muscle, Optical tomography, Attenuation coefficient, Duchenne muscular dystrophies, Healthy tissues, Muscle tissues, Muscular dystrophy, Parametric imaging, Skeletal muscle, Standard errors, Mammals, animal model, animal tissue, article, attenuation coefficient, controlled study, image analysis, male, mouse, muscle fibril, muscular dystrophy, necrosis, nonhuman, optical coherence tomography, physical parameters, quantitative analysis, skeletal muscle
Depositing User :	Maria Rodriguez-Marquez
Date Deposited :	05 Jun 2018 09:15
Last Modified :	19 Sep 2018 11:32
URI:	http://epubs.surrey.ac.uk/id/eprint/846797

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