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Optical coherence micro-elastography: Mechanical-contrast imaging of tissue microstructure

Kennedy, B.F., Mclaughlin, R.A., Kennedy, K.M., Chin, L., Curatolo, A., Tien, A., Latham, B., Saunders, C.M. and Sampson, David (2014) Optical coherence micro-elastography: Mechanical-contrast imaging of tissue microstructure Biomedical Optics Express, 5 (7). pp. 2113-2124.

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We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro- elastography incorporates common-path interferometry, weighted averaging of the complex OCT signal and weighted least-squares regression. Using three-dimensional phase unwrapping, we have increased the maximum detectable strain eleven-fold over no unwrapping and the minimum detectable strain is 2.6 με. We demonstrate the potential of mechanical over optical contrast for visualizing micro-scale tissue structures in human breast cancer pathology and lymph node morphology.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Kennedy, B.F.
Mclaughlin, R.A.
Kennedy, K.M.
Chin, L.
Curatolo, A.
Tien, A.
Latham, B.
Saunders, C.M.
Date : 2014
DOI : 10.1364/BOE.5.002113
Uncontrolled Keywords : Histology, Medical imaging, Optical tomography, Axial displacements, Compressive loading, Human breast cancer, Lymph node tissues, Optical coherence elastography, Tissue microstructures, Weighted averaging, Weighted least squares, Tissue, algorithm, article, biomechanics, breast cancer, cancer tissue, clinical article, compression, contrast, elastography, histopathology, human, human tissue, image analysis, imaging phantom, interferometry, lymph node, optical coherence micro elastography, optical coherence tomography, optical resolution, sensitivity analysis, signal noise ratio, signal processing, three dimensional imaging, tissue structure
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 09:04
Last Modified : 19 Sep 2018 11:32

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