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Optical coherence elastography

Kennedy, B.F., Kennedy, K.M., Oldenburg, A.L., Adie, S.G., Boppart, S.A. and Sampson, David (2015) Optical coherence elastography In: Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, pp. 1007-1054. ISBN 978-3-319-06418-5

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The mechanical properties of tissue are pivotal in its function and behavior, and are often modified by disease. From the nano- to the macro-scale, many tools have been developed to measure tissue mechanical properties, both to understand the contribution of mechanics in the origin of disease and to improve diagnosis. Optical coherence elastography is applicable to the intermediate scale, between that of cells and whole organs, which is critical in the progression of many diseases and not widely studied to date. In optical coherence elastography, a mechanical load is imparted to a tissue and the resulting deformation is measured using optical coherence tomography. The deformation is used to deduce a mechanical parameter, e.g., Young's modulus, which is mapped into an image, known as an elastogram. In this chapter, we review the development of optical coherence elastography and report on the latest developments. We provide a focus on the underlying principles and assumptions, techniques to measure deformation, loading mechanisms, imaging probes and modeling, including the inverse elasticity problem.

Item Type: Book Section
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Kennedy, B.F.
Kennedy, K.M.
Oldenburg, A.L.
Adie, S.G.
Boppart, S.A.
Editors :
Drexler, W
Fujimoto, J
Date : 2015
DOI : 10.1007/978-3-319-06419-2_32
Uncontrolled Keywords : Biomechanics, Cell mechanics, Elastography, Optical elastography, Soft tissue, Tissue mechanics
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 08:18
Last Modified : 06 Jul 2019 05:25

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