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In vivo optical elastography: Stress and strain imaging of human skin lesions

Es'haghian, S., Gong, P., Kennedy, K.M., Wijesinghe, P., Sampson, David, McLaughlin, R.A. and Kennedy, B.F. (2015) In vivo optical elastography: Stress and strain imaging of human skin lesions

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Probing the mechanical properties of skin at high resolution could aid in the assessment of skin pathologies by, for example, detecting the extent of cancerous skin lesions and assessing pathology in burn scars. Here, we present two elastography techniques based on optical coherence tomography (OCT) to probe the local mechanical properties of skin. The first technique, optical palpation, is a high-resolution tactile imaging technique, which uses a complaint silicone layer positioned on the tissue surface to measure spatially-resolved stress imparted by compressive loading. We assess the performance of optical palpation, using a handheld imaging probe on a skin-mimicking phantom, and demonstrate its use on human skin. The second technique is a strain imaging technique, phase-sensitive compression OCE that maps depth-resolved mechanical variations within skin. We show preliminary results of in vivo phase-sensitive compression OCE on a human skin lesion.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Es'haghian, S.
Gong, P.
Kennedy, K.M.
Wijesinghe, P.
McLaughlin, R.A.
Kennedy, B.F.
Date : 2015
DOI : 10.1117/12.2078706
Uncontrolled Keywords : Optical coherence elastography, Optical coherence tomography, Optical palpation, Skin lesion, Tactile imaging, Dermatology, Imaging techniques, Mechanical properties, Medical imaging, Optical tomography, Pathology, Probes, Silicones, Stress analysis, Tissue, Tomography, Compressive loading, Local mechanical properties, Mechanical variations, Optical coherence elastography, Optical elastography, Optical palpation, Skin lesion, Spatially resolved, Biomechanics
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 04 Jun 2018 10:05
Last Modified : 19 Sep 2018 11:32

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