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Parametric imaging of viscoelasticity using optical coherence elastography

Wijesinghe, P., McLaughlin, R.A., Sampson, David and Kennedy, B.F. (2015) Parametric imaging of viscoelasticity using optical coherence elastography Physics in Medicine and Biology, 60 (6). pp. 2293-2307.

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We demonstrate imaging of soft tissue viscoelasticity using optical coherence elastography. Viscoelastic creep deformation is induced in tissue using step-like compressive loading and the resulting time-varying deformation is measured using phase-sensitive optical coherence tomography. From a series of co-located B-scans, we estimate the local strain rate as a function of time, and parameterize it using a four-parameter Kelvin-Voigt model of viscoelastic creep. The estimated viscoelastic strain and time constant are used to visualize viscoelastic creep in 2D, dual-parameter viscoelastograms. We demonstrate our technique on six silicone tissue-simulating phantoms spanning a range of viscoelastic parameters. As an example in soft tissue, we report viscoelastic contrast between muscle and connective tissue in fresh, ex vivo rat gastrocnemius muscle and mouse abdominal transection. Imaging viscoelastic creep deformation has the potential to provide complementary contrast to existing imaging modalities, and may provide greater insight into disease pathology.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences
Faculty of Health and Medical Sciences
Authors :
Wijesinghe, P.
McLaughlin, R.A.
Kennedy, B.F.
Date : 2015
DOI : 10.1088/0031-9155/60/6/2293
Uncontrolled Keywords : biomechanical properties, optical coherence elastography, viscoelastic creep, Collagen, Deformation, Medical imaging, Muscle, Musculoskeletal system, Optical properties, Optical tomography, Silicones, Strain rate, Tissue, Viscoelasticity, Biomechanical properties, Compressive loading, Gastrocnemius muscle, Optical coherence elastography, Phase-sensitive optical coherence tomographies, Tissue simulating phantoms, Visco-elastic parameters, Viscoelastic creep, Creep, animal, elasticity, elastography, image quality, mouse, optical coherence tomography, procedures, rat, theoretical model, viscosity, Animals, Elasticity, Elasticity Imaging Techniques, Mice, Models, Theoretical, Phantoms, Imaging, Rats, Tomography, Optical Coherence, Viscosity
Depositing User : Maria Rodriguez-Marquez
Date Deposited : 05 Jun 2018 08:44
Last Modified : 19 Sep 2018 11:32

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