Parametric imaging of viscoelasticity using optical coherence elastography
Wijesinghe, P., McLaughlin, R.A., Sampson, David and Kennedy, B.F. (2015) Parametric imaging of viscoelasticity using optical coherence elastography Physics in Medicine and Biology, 60 (6). pp. 2293-2307.
Full text not available from this repository.Abstract
We demonstrate imaging of soft tissue viscoelasticity using optical coherence elastography. Viscoelastic creep deformation is induced in tissue using step-like compressive loading and the resulting time-varying deformation is measured using phase-sensitive optical coherence tomography. From a series of co-located B-scans, we estimate the local strain rate as a function of time, and parameterize it using a four-parameter Kelvin-Voigt model of viscoelastic creep. The estimated viscoelastic strain and time constant are used to visualize viscoelastic creep in 2D, dual-parameter viscoelastograms. We demonstrate our technique on six silicone tissue-simulating phantoms spanning a range of viscoelastic parameters. As an example in soft tissue, we report viscoelastic contrast between muscle and connective tissue in fresh, ex vivo rat gastrocnemius muscle and mouse abdominal transection. Imaging viscoelastic creep deformation has the potential to provide complementary contrast to existing imaging modalities, and may provide greater insight into disease pathology.
Item Type: | Article | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Divisions : |
Faculty of Engineering and Physical Sciences Faculty of Health and Medical Sciences |
|||||||||||||||
Authors : |
|
|||||||||||||||
Date : | 2015 | |||||||||||||||
DOI : | 10.1088/0031-9155/60/6/2293 | |||||||||||||||
Uncontrolled Keywords : | biomechanical properties, optical coherence elastography, viscoelastic creep, Collagen, Deformation, Medical imaging, Muscle, Musculoskeletal system, Optical properties, Optical tomography, Silicones, Strain rate, Tissue, Viscoelasticity, Biomechanical properties, Compressive loading, Gastrocnemius muscle, Optical coherence elastography, Phase-sensitive optical coherence tomographies, Tissue simulating phantoms, Visco-elastic parameters, Viscoelastic creep, Creep, animal, elasticity, elastography, image quality, mouse, optical coherence tomography, procedures, rat, theoretical model, viscosity, Animals, Elasticity, Elasticity Imaging Techniques, Mice, Models, Theoretical, Phantoms, Imaging, Rats, Tomography, Optical Coherence, Viscosity | |||||||||||||||
Depositing User : | Maria Rodriguez-Marquez | |||||||||||||||
Date Deposited : | 05 Jun 2018 08:44 | |||||||||||||||
Last Modified : | 19 Sep 2018 11:32 | |||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/846779 |
Actions (login required)
![]() |
View Item |
Downloads
Downloads per month over past year